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dc.contributor.authorBouza, Carmen 
dc.contributor.authorLopez-Cuadrado, Teresa 
dc.contributor.authorAmate, Jose Maria 
dc.date.accessioned2019-12-05T12:05:58Z
dc.date.available2019-12-05T12:05:58Z
dc.date.issued2010-12-02
dc.identifier.citationBMC Public Health. 2010 Dec 2;10:745.es_ES
dc.identifier.issn1471-2458es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8746
dc.description.abstractBACKGROUND: Physical disease remains a challenge in patients with schizophrenia. Our objective was to determine the epidemiological characteristics and burden of physical disease in hospitalized patients with schizophrenia. METHODS: We analyzed the 2004 Spanish National Hospital Discharge Registry, identified records coded for schizophrenia (295.xx) and characterized the physical diseases using the ICD-9 system and the Charlson Index. We also calculated standardized mortality ratios (SMRs) versus the general population adjusted by age and calendar time. RESULTS: A total of 16, 776 cases (mean age: 43 years, 65% males) were considered for analysis. Overall, 61% of cases had at least one ICD-9 physical code and 32% had more than one ICD-9 code. The Charlson index indicated that 20% of cases had a physical disease of known clinical impact and prognostic significance. Physical disease appeared early in life (50% of cases were 15-31 years of age) and increased rapidly in incidence with age. Thus, for patients aged 53 years or more, 84% had at least one physical ICD-9 code. Apart from substance abuse and addiction, the most prevalent diseases were endocrine (16%), circulatory (15%), respiratory (15%), injury-poisoning (11%), and digestive (10%). There were gender-related differences in disease burden and type of disease. In-hospital mortality significantly correlated with age, the Charlson Index and several ICD-9 groups of physical disease. Physical disease was associated with an overall 3.6-fold increase in SMRs compared with the general population. CONCLUSIONS: This study provides the first nationally representative estimate of the prevalence and characteristics of physical disease in hospitalized patients with schizophrenia in Spain. Our results indicate that schizophrenia is associated with a substantial burden of physical comorbidities; that these comorbidities appear early in life; and that they have a substantial impact on mortality. This information raises concerns about the consequences and causes of physical disorders in patients with schizophrenia. Additionally, it will help to guide the design and implementation of preventive and therapeutic programs from the viewpoint of clinical care and in terms of health-care service planning.es_ES
dc.description.sponsorshipFunding for this study was provided by the Spanish R&D Grant no. PI06/90571. The funding body had no further role in study design, data collection, analysis, interpretation, writing of the report, or the decision to submit the paper for publicationes_ES
dc.language.isoenges_ES
dc.publisherBioMed Centrales_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAdolescent es_ES
dc.subject.meshAged es_ES
dc.subject.meshAged, 80 and over es_ES
dc.subject.meshCause of Death es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHospitalization es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInternational Classification of Diseases es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshSchizophrenia es_ES
dc.subject.meshSeverity of Illness Index es_ES
dc.subject.meshSpain es_ES
dc.subject.meshComorbidity es_ES
dc.subject.meshHospital Mortality es_ES
dc.titlePhysical disease in schizophrenia: a population-based analysis in Spaines_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID21126335es_ES
dc.format.volume10es_ES
dc.format.number1es_ES
dc.format.page745es_ES
dc.identifier.doi10.1186/1471-2458-10-745es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1471-2458es_ES
dc.relation.publisherversionhttps://doi.org/10.1186/1471-2458-10-745es_ES
dc.identifier.journalBMC public healthes_ES
dc.repisalud.centroISCIII::Agencia de Evaluación de Tecnologías Sanitariases_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI06/90571es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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