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dc.contributor.authorMonge-Maillo, Begoña
dc.contributor.authorNorman, Francesca F
dc.contributor.authorCruz, Israel 
dc.contributor.authorAlvar, Jorge
dc.contributor.authorLópez-Vélez, Rogelio
dc.date.accessioned2019-12-02T13:16:10Z
dc.date.available2019-12-02T13:16:10Z
dc.date.issued2014-08
dc.identifier.citationPLoS Negl Trop Dis. 2014 Aug 21;8(8):e3021.es_ES
dc.identifier.issn1935-2735es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8732
dc.description.abstractVisceral leishmaniasis is hypoendemic in Mediterranean countries, where it is caused by the flagellate protozoan Leishmania infantum. VL cases in this area account for 5%-6% of the global burden. Cases of Leishmania/HIV coinfection have been reported in the Mediterranean region, mainly in France, Italy, Portugal, and Spain. Since highly active antiretroviral therapy was introduced in 1997, a marked decrease in the number of coinfected cases in this region has been reported. The development of new diagnostic methods to accurately identify level of parasitemia and the risk of relapse is one of the main challenges in improving the treatment of coinfected patients. Clinical trials in the Mediterranean region are needed to determine the most adequate therapeutic options for Leishmania/HIV patients as well as the indications and regimes for secondary prophylaxis. This article reviews the epidemiological, diagnostic, clinical, and therapeutic aspects of Leishmania/HIV coinfection in the Mediterranean region.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAntiretroviral Therapy, Highly Active es_ES
dc.subject.meshCD4 Lymphocyte Count es_ES
dc.subject.meshCoinfection es_ES
dc.subject.meshHIV Infections es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInterferon-gamma es_ES
dc.subject.meshLeishmaniasis, Visceral es_ES
dc.subject.meshMediterranean Region es_ES
dc.subject.meshPolymerase Chain Reaction es_ES
dc.titleVisceral leishmaniasis and HIV coinfection in the Mediterranean regiones_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID25144380es_ES
dc.format.volume8es_ES
dc.format.number8es_ES
dc.format.pagee3021es_ES
dc.identifier.doi10.1371/journal.pntd.0003021es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1935-2735es_ES
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pntd.0003021es_ES
dc.identifier.journalPLoS neglected tropical diseaseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional