Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8581
Título
G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub
Autor(es)
Fecha de publicación
2019-11
Cita
Cell Mol Life Sci. 2019; 76(22):4423-4446
Idioma
Inglés
Tipo de documento
journal article
Resumen
Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an extensive number of non-GPCR cellular partners. GRK2 multifunctionality arises from its multidomain structure and from complex mechanisms of regulation of its expression levels, activity, and localization within the cell, what allows the precise spatio-temporal shaping of GRK2 targets. A better understanding of the GRK2 interactome and its modulation mechanisms is helping to identify the GRK2-interacting proteins and its substrates involved in the participation of this kinase in different cellular processes and pathophysiological contexts.
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