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dc.contributor.authorMelero, Jose Antonio 
dc.contributor.authorMas-Lloret, Vicente 
dc.contributor.authorMcLellan, Jason S
dc.date.accessioned2019-11-08T11:55:02Z
dc.date.available2019-11-08T11:55:02Z
dc.date.issued2017
dc.identifier.citationVaccine. 2017 Jan 11;35(3):461-468. doi: 10.1016/j.vaccine.2016.09.045. Epub 2016 Sep 28.es_ES
dc.identifier.issn0264-410Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8566
dc.description.abstractExtraordinary progress in the structure and immunobiology of the human respiratory syncytial virus glycoproteins has been accomplished during the last few years. Determination of the fusion (F) glycoprotein structure folded in either the prefusion or the postfusion conformation was an inspiring breakthrough not only to understand the structural changes associated with the membrane fusion process but additionally to appreciate the antigenic intricacies of the F protein. Furthermore, these developments have opened new avenues for structure-based designs of promising hRSV vaccine candidates. Finally, recent advances in our knowledge of the attachment (G) glycoprotein and its interaction with cell-surface receptors have revitalized interest in this molecule as a vaccine, as well as its role in hRSV immunobiology.es_ES
dc.description.sponsorshipWork in the Madrid lab is currently funded by grant SAF2015-67033-R from Plan Nacional de I+D+I. J.S.M is supported in part by award P20GM113132 from the National Institute of General Medical Sciences of the National Institutes of Health.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRSV glycoproteins and vaccine developmentes_ES
dc.subject.meshAntigens, Viral es_ES
dc.subject.meshGlycoproteins es_ES
dc.subject.meshHumans es_ES
dc.subject.meshProtein Conformation es_ES
dc.subject.meshRespiratory Syncytial Virus Vaccines es_ES
dc.subject.meshRespiratory Syncytial Virus, Humanes_ES
dc.subject.meshVirus Internalization es_ES
dc.titleStructural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine developmentes_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID27692522es_ES
dc.format.volume35es_ES
dc.format.number3es_ES
dc.format.page461-468es_ES
dc.identifier.doi10.1016/j.vaccine.2016.09.045es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1873-2518es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.vaccine.2016.09.045es_ES
dc.identifier.journalVaccinees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-67033-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/P20GM113132es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional