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dc.contributor.authorYangzom, Thinley
dc.contributor.authorCruz, Israel 
dc.contributor.authorBern, Caryn
dc.contributor.authorArgaw, Daniel
dc.contributor.authorden Boer, Margriet
dc.contributor.authorVélez, Iván Dario
dc.contributor.authorBhattacharya, Sujit K
dc.contributor.authorMolina, Ricardo 
dc.contributor.authorAlvar, Jorge
dc.identifier.citationAm J Trop Med Hyg. 2012 Dec;87(6):1028-37. doi: 10.4269/ajtmh.2012.12-0211. Epub 2012 Oct 22.es_ES
dc.description.abstractVisceral leishmaniasis was first reported in Bhutan in 2006. We conducted studies of the parasite, possible vectors and reservoirs, and leishmanin skin test and risk factor surveys in three villages. Nineteen cases were reported from seven districts. Parasite typing yielded two novel microsatellite sequences, both related to Indian L. donovani. In one case village, 40 (18.5%) of 216 participants had positive leishmanin skin test results, compared with 3 (4.2%) of 72 in the other case village and 0 of 108 in the control village. Positive results were strongly associated with the village and increasing age. None of the tested dogs were infected. Eighteen sand flies were collected, 13 Phlebotomus species and 5 Sergentomyia species; polymerase chain reaction for leishmanial DNA was negative. This assessment suggests that endemic visceral leishmaniasis transmission has occurred in diverse locations in Bhutan. Surveillance, case investigations, and further parasite, vector, and reservoir studies are needed. The potential protective impact of bed nets should be evaluated.es_ES
dc.description.sponsorshipThis assessment was made thanks to the support that the Spanish Agency for International Cooperation for Development (AECID) provides to WHO for the control of visceral leishmaniasis. We are grateful to Rinzin Namgay from the Ministry of Health, Bhutan and the staff from Karuna House canine shelter in Trashigang, Bhutan, for their support during the field study.es_ES
dc.publisherAmerican Society of Tropical Medicine and Hygiene (ASTMH) es_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshAdult es_ES
dc.subject.meshBase Sequence es_ES
dc.subject.meshBhutan es_ES
dc.subject.meshDNA, Intergenic es_ES
dc.subject.meshDNA, Protozoan es_ES
dc.subject.meshEndemic Diseases es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLeishmania donovani es_ES
dc.subject.meshLeishmania infantum es_ES
dc.subject.meshLeishmaniasis, Visceral es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPhylogeny es_ES
dc.subject.meshYoung Adult es_ES
dc.titleEndemic transmission of visceral leishmaniasis in Bhutanes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.contributor.funderAgencia Española de Cooperación Internacional para el Desarrollo 
dc.identifier.journalThe American journal of tropical medicine and hygienees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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