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dc.contributor.author | Sande-Melon, Marcos | |
dc.contributor.author | Marques, Ines Joao | |
dc.contributor.author | Galardi-Castilla, Maria | |
dc.contributor.author | Langa, Xavier | |
dc.contributor.author | Pérez-López, María | |
dc.contributor.author | Botos, Marius-Alexandru | |
dc.contributor.author | Sanchez-Iranzo, Hector | |
dc.contributor.author | Guzman-Martinez, Gabriela | |
dc.contributor.author | Ferreira Francisco, David Miguel | |
dc.contributor.author | Pavlinic, Dinko | |
dc.contributor.author | Benes, Vladimir | |
dc.contributor.author | Bruggmann, Rémy | |
dc.contributor.author | Mercader, Nadia | |
dc.date.accessioned | 2019-10-31T10:44:45Z | |
dc.date.available | 2019-10-31T10:44:45Z | |
dc.date.issued | 2019-10 | |
dc.identifier.citation | Cell Rep. 2019; 29(4):1041-1054 | es_ES |
dc.identifier.issn | 22111247 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8539 | |
dc.description.abstract | During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identify a subset of preexistent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded after cryoinjury. Genetic ablation of sox10+ cardiomyocytes impairs cardiac regeneration, revealing that these cells play a role in heart regeneration. | es_ES |
dc.description.sponsorship | This work has been funded by the Spanish Ministry of Economy and Competitiveness (BFU2014–56970–P), the Swiss National Science Foundation (grant 31003A_159721), the ERC (starting grant 337703–zebra–Heart), Comunidad de Madrid (FIBROTEAM S2010/BMD-2321), and co-funding by Fondo Europeo de Desarrollo Regional (FEDER). I.J.M. was supported by Marie Curie Slodowska fellowship (PIEF-A-2012-330728). D.F. was supported by BtRAIN (European Brain Barriers Training Network) (H2020-MSCA-ITN-2015, n 675619). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovacion y Universidades (MCNU), and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cardiomyocyte proliferation | es_ES |
dc.subject | Heart regeneration | es_ES |
dc.subject | Sox10 | es_ES |
dc.subject | Zebrafish | es_ES |
dc.title | Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 31644901 | es_ES |
dc.format.volume | 29 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | 1041-1054.e5 | es_ES |
dc.identifier.doi | 10.1016/j.celrep.2019.09.041 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Swiss National Science Foundation | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2211-1247 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.celrep.2019.09.041 | es_ES |
dc.identifier.journal | Cell reports | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Desarrollo del Epicardio y su Papel en la Regeneración | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/337703 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/330728 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/675619 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BFU2014–56970–P | es_ES |
dc.rights.accessRights | open access | es_ES |