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dc.contributor.authorAbascal, Federico
dc.contributor.authorCorvelo, André
dc.contributor.authorCruz, Fernando
dc.contributor.authorVillanueva-Cañas, José L
dc.contributor.authorVlasova, Anna
dc.contributor.authorMarcet-Houben, Marina
dc.contributor.authorMartínez-Cruz, Begoña
dc.contributor.authorCheng, Jade Yu
dc.contributor.authorPrieto, Pablo
dc.contributor.authorQuesada, Víctor
dc.contributor.authorQuilez, Javier
dc.contributor.authorLi, Gang
dc.contributor.authorGarcía, Francisca
dc.contributor.authorRubio-Camarillo, Miriam
dc.contributor.authorFrias, Leonor
dc.contributor.authorRibeca, Paolo
dc.contributor.authorCapella-Gutierrez, Salvador Jesus 
dc.contributor.authorRodríguez, José M
dc.contributor.authorCâmara, Francisco
dc.contributor.authorLowy, Ernesto
dc.contributor.authorCozzuto, Luca
dc.contributor.authorErb, Ionas
dc.contributor.authorTress, Michael L
dc.contributor.authorRodriguez-Ales, Jose L
dc.contributor.authorRuiz-Orera, Jorge
dc.contributor.authorReverter, Ferran
dc.contributor.authorCasas-Marce, Mireia
dc.contributor.authorSoriano, Laura
dc.contributor.authorArango, Javier R
dc.contributor.authorDerdak, Sophia
dc.contributor.authorGalán, Beatriz
dc.contributor.authorBlanc, Julie
dc.contributor.authorGut, Marta
dc.contributor.authorLorente-Galdos, Belen
dc.contributor.authorAndrés-Nieto, Marta
dc.contributor.authorLópez-Otín, Carlos
dc.contributor.authorValencia, Alfonso 
dc.contributor.authorGut, Ivo
dc.contributor.authorGarcía, José L
dc.contributor.authorGuigó, Roderic
dc.contributor.authorMurphy, William J
dc.contributor.authorRuiz-Herrera, Aurora
dc.contributor.authorMarques-Bonet, Tomas
dc.contributor.authorRoma, Guglielmo
dc.contributor.authorNotredame, Cedric
dc.contributor.authorMailund, Thomas
dc.contributor.authorAlbà, M Mar
dc.contributor.authorGabaldón, Toni
dc.contributor.authorAlioto, Tyler
dc.contributor.authorGodoy, José A
dc.date.accessioned2019-10-21T11:22:12Z
dc.date.available2019-10-21T11:22:12Z
dc.date.issued2016-12-14
dc.identifier.citationGenome Biol. 2016 ;17(1):251.es_ES
dc.identifier.issn1474-760Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8510
dc.description.abstractBACKGROUND: Genomic studies of endangered species provide insights into their evolution and demographic history, reveal patterns of genomic erosion that might limit their viability, and offer tools for their effective conservation. The Iberian lynx (Lynx pardinus) is the most endangered felid and a unique example of a species on the brink of extinction. RESULTS: We generate the first annotated draft of the Iberian lynx genome and carry out genome-based analyses of lynx demography, evolution, and population genetics. We identify a series of severe population bottlenecks in the history of the Iberian lynx that predate its known demographic decline during the 20th century and have greatly impacted its genome evolution. We observe drastically reduced rates of weak-to-strong substitutions associated with GC-biased gene conversion and increased rates of fixation of transposable elements. We also find multiple signatures of genetic erosion in the two remnant Iberian lynx populations, including a high frequency of potentially deleterious variants and substitutions, as well as the lowest genome-wide genetic diversity reported so far in any species. CONCLUSIONS: The genomic features observed in the Iberian lynx genome may hamper short- and long-term viability through reduced fitness and adaptive potential. The knowledge and resources developed in this study will boost the research on felid evolution and conservation genomics and will benefit the ongoing conservation and management of this emblematic species.es_ES
dc.language.isoenges_ES
dc.publisherBioMed Central (BMC) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectConservation genomicses_ES
dc.subjectGenetic diversityes_ES
dc.subjectGenetic driftes_ES
dc.subjectInbreedinges_ES
dc.subjectLynxes_ES
dc.subject.meshAnimals es_ES
dc.subject.meshEndangered Species es_ES
dc.subject.meshGenetic Variation es_ES
dc.subject.meshHigh-Throughput Nucleotide Sequencing es_ES
dc.subject.meshLynx es_ES
dc.subject.meshMolecular Sequence Annotation es_ES
dc.subject.meshSequence Analysis, DNA es_ES
dc.subject.meshGenetics, Population es_ES
dc.subject.meshGenome es_ES
dc.titleExtreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynxes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID27964752es_ES
dc.format.volume17es_ES
dc.format.number1es_ES
dc.format.page251es_ES
dc.identifier.doi10.1186/s13059-016-1090-1es_ES
dc.contributor.funderBanco Santander 
dc.contributor.funderUnión Europea. Comisión Europea. 7 Programa Marco 
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderInstitució Catalana de Recerca i Estudis Avançats 
dc.contributor.funderBiotechnology and Biological Sciences Research Council (Reino Unido) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1474-760Xes_ES
dc.relation.publisherversionhttps://doi.org/10.1186/s13059-016-1090-1es_ES
dc.identifier.journalGenome biologyes_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Antiguos CNIOes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/EC/FP7/264125es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/SEV-2012-0262es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/SEV-2012-0208es_ES
dc.rights.accessRightsopen accesses_ES


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Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional