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dc.contributor.authorFontenete, Silvia
dc.contributor.authorPeña-Jiménez, Daniel 
dc.contributor.authorPerez-Moreno, Mirna Alicia 
dc.date.accessioned2019-10-16T11:48:28Z
dc.date.available2019-10-16T11:48:28Z
dc.date.issued2017-06-27
dc.identifier.citationF1000Res. 2017;6:1010es_ES
dc.identifier.issn2046-1402es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8497
dc.description.abstractThis short insight covers some of the recent topics relevant to the field of cadherin-catenin adhesion in mediating connections between different cell types, so-called heterotypic or heterocellular connections, in both homeostasis and cancer. These scientific discoveries are increasing our understanding of how multiple cells residing in complex tissues can be instructed by cadherin adhesion receptors to regulate tissue architecture and function and how these cadherin-mediated heterocellular connections spur tumor growth and the acquisition of malignant characteristics in tumor cells. Overall, the findings that have emerged over the past few years are elucidating the complexity of the functional roles of the cadherin-catenin complexes. Future exciting research lies ahead in order to understand the physical basis of these heterotypic interactions and their influence on the behavior of heterogeneous cellular populations as well as their roles in mediating phenotypic and genetic changes as cells evolve through complex environments during morphogenesis and cancer.es_ES
dc.description.sponsorshipThe Perez-Moreno lab is supported by grants from the Spanish Ministry of Economy and Competitiveness/European Regional Development Fund (ERDF), European Union (BFU2015-71376-R), and the Worldwide Cancer Research UK Foundation (15-1219 to Mirna Perez-Moreno). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.language.isoenges_ES
dc.publisherF1000 es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCadherin adhesiones_ES
dc.subjectCadherin catenines_ES
dc.subjectCanceres_ES
dc.subjectHeterocellular adhesiones_ES
dc.subjectHeterotypic adhesiones_ES
dc.titleHeterocellular cadherin connections: coordinating adhesive cues in homeostasis and canceres_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID28721207es_ES
dc.format.volume6es_ES
dc.format.page1010es_ES
dc.identifier.doi10.12688/f1000research.11357.1es_ES
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.12688/f1000research.11357.1es_ES
dc.identifier.journalF1000Researches_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Antiguos CNIOes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/BFU2015-71376-Res_ES
dc.rights.accessRightsopen accesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional