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dc.contributor.author | Fontenete, Silvia | |
dc.contributor.author | Peña-Jiménez, Daniel | |
dc.contributor.author | Perez-Moreno, Mirna Alicia | |
dc.date.accessioned | 2019-10-16T11:48:28Z | |
dc.date.available | 2019-10-16T11:48:28Z | |
dc.date.issued | 2017-06-27 | |
dc.identifier.citation | F1000Res. 2017;6:1010 | es_ES |
dc.identifier.issn | 2046-1402 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8497 | |
dc.description.abstract | This short insight covers some of the recent topics relevant to the field of cadherin-catenin adhesion in mediating connections between different cell types, so-called heterotypic or heterocellular connections, in both homeostasis and cancer. These scientific discoveries are increasing our understanding of how multiple cells residing in complex tissues can be instructed by cadherin adhesion receptors to regulate tissue architecture and function and how these cadherin-mediated heterocellular connections spur tumor growth and the acquisition of malignant characteristics in tumor cells. Overall, the findings that have emerged over the past few years are elucidating the complexity of the functional roles of the cadherin-catenin complexes. Future exciting research lies ahead in order to understand the physical basis of these heterotypic interactions and their influence on the behavior of heterogeneous cellular populations as well as their roles in mediating phenotypic and genetic changes as cells evolve through complex environments during morphogenesis and cancer. | es_ES |
dc.description.sponsorship | The Perez-Moreno lab is supported by grants from the Spanish Ministry of Economy and Competitiveness/European Regional Development Fund (ERDF), European Union (BFU2015-71376-R), and the Worldwide Cancer Research UK Foundation (15-1219 to Mirna Perez-Moreno). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | F1000 | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Cadherin adhesion | es_ES |
dc.subject | Cadherin catenin | es_ES |
dc.subject | Cancer | es_ES |
dc.subject | Heterocellular adhesion | es_ES |
dc.subject | Heterotypic adhesion | es_ES |
dc.title | Heterocellular cadherin connections: coordinating adhesive cues in homeostasis and cancer | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 28721207 | es_ES |
dc.format.volume | 6 | es_ES |
dc.format.page | 1010 | es_ES |
dc.identifier.doi | 10.12688/f1000research.11357.1 | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.12688/f1000research.11357.1 | es_ES |
dc.identifier.journal | F1000Research | es_ES |
dc.repisalud.institucion | CNIO | es_ES |
dc.repisalud.orgCNIO | CNIO::Grupos de investigación::Antiguos CNIO | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/BFU2015-71376-R | es_ES |
dc.rights.accessRights | open access | es_ES |