Show simple item record

dc.contributor.authorLecarpentier, Julie
dc.contributor.authorSilvestri, Valentina
dc.contributor.authorKuchenbaecker, Karoline B
dc.contributor.authorBarrowdale, Daniel
dc.contributor.authorDennis, Joe
dc.contributor.authorMcGuffog, Lesley
dc.contributor.authorSoucy, Penny
dc.contributor.authorLeslie, Goska
dc.contributor.authorRizzolo, Piera
dc.contributor.authorNavazio, Anna Sara
dc.contributor.authorValentini, Virginia
dc.contributor.authorZelli, Veronica
dc.contributor.authorLee, Andrew
dc.contributor.authorAmin Al Olama, Ali
dc.contributor.authorTyrer, Jonathan P
dc.contributor.authorSouthey, Melissa
dc.contributor.authorJohn, Esther M
dc.contributor.authorConner, Thomas A
dc.contributor.authorGoldgar, David E
dc.contributor.authorBuys, Saundra S
dc.contributor.authorJanavicius, Ramunas
dc.contributor.authorSteele, Linda
dc.contributor.authorDing, Yuan Chun
dc.contributor.authorNeuhausen, Susan L
dc.contributor.authorHansen, Thomas V O
dc.contributor.authorOsorio, Ana 
dc.contributor.authorWeitzel, Jeffrey N
dc.contributor.authorToss, Angela
dc.contributor.authorMedici, Veronica
dc.contributor.authorCortesi, Laura
dc.contributor.authorZanna, Ines
dc.contributor.authorPalli, Domenico
dc.contributor.authorRadice, Paolo
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorPeissel, Bernard
dc.contributor.authorAzzollini, Jacopo
dc.contributor.authorViel, Alessandra
dc.contributor.authorCini, Giulia
dc.contributor.authorDamante, Giuseppe
dc.contributor.authorTommasi, Stefania
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorFostira, Florentia
dc.contributor.authorHamann, Ute
dc.contributor.authorEvans, D Gareth
dc.contributor.authorHenderson, Alex
dc.contributor.authorBrewer, Carole
dc.contributor.authorEccles, Diana
dc.contributor.authorCook, Jackie
dc.contributor.authorOng, Kai-Ren
dc.contributor.authorWalker, Lisa
dc.contributor.authorSide, Lucy E
dc.contributor.authorPorteous, Mary E
dc.contributor.authorDavidson, Rosemarie
dc.contributor.authorHodgson, Shirley
dc.contributor.authorFrost, Debra
dc.contributor.authorAdlard, Julian
dc.contributor.authorIzatt, Louise
dc.contributor.authorEeles, Ros
dc.contributor.authorEllis, Steve
dc.contributor.authorTischkowitz, Marc
dc.contributor.authorGodwin, Andrew K
dc.contributor.authorMeindl, Alfons
dc.contributor.authorGehrig, Andrea
dc.contributor.authorDworniczak, Bernd
dc.contributor.authorSutter, Christian
dc.contributor.authorEngel, Christoph
dc.contributor.authorNiederacher, Dieter
dc.contributor.authorSteinemann, Doris
dc.contributor.authorHahnen, Eric
dc.contributor.authorHauke, Jan
dc.contributor.authorRhiem, Kerstin
dc.contributor.authorKast, Karin
dc.contributor.authorArnold, Norbert
dc.contributor.authorDitsch, Nina
dc.contributor.authorWang-Gohrke, Shan
dc.contributor.authorWappenschmidt, Barbara
dc.contributor.authorWand, Dorothea
dc.contributor.authorLasset, Christine
dc.contributor.authorStoppa-Lyonnet, Dominique
dc.contributor.authorBelotti, Muriel
dc.contributor.authorDamiola, Francesca
dc.contributor.authorBarjhoux, Laure
dc.contributor.authorMazoyer, Sylvie
dc.contributor.authorVan Heetvelde, Mattias
dc.contributor.authorPoppe, Bruce
dc.contributor.authorDe Leeneer, Kim
dc.contributor.authorClaes, Kathleen B M
dc.contributor.authorde la Hoya, Miguel
dc.contributor.authorGarcia-Barberan, Vanesa
dc.contributor.authorCaldes, Trinidad
dc.contributor.authorPerez Segura, Pedro
dc.contributor.authorKiiski, Johanna I
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorKhan, Sofia
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorvan Asperen, Christi J
dc.contributor.authorVaszko, Tibor
dc.contributor.authorKasler, Miklos
dc.contributor.authorOlah, Edith
dc.contributor.authorBalmaña, Judith
dc.contributor.authorGutiérrez-Enríquez, Sara
dc.contributor.authorDiez, Orland
dc.contributor.authorTeulé, Alex
dc.contributor.authorIzquierdo, Angel
dc.contributor.authorDarder, Esther
dc.contributor.authorBrunet, Joan
dc.contributor.authorDel Valle, Jesús
dc.contributor.authorFeliubadalo, Lidia
dc.contributor.authorPujana, Miquel Angel
dc.contributor.authorLazaro, Conxi
dc.contributor.authorArason, Adalgeir
dc.contributor.authorAgnarsson, Bjarni A
dc.contributor.authorJohannsson, Oskar Th
dc.contributor.authorBarkardottir, Rosa B
dc.contributor.authorAlducci, Elisa
dc.contributor.authorTognazzo, Silvia
dc.contributor.authorMontagna, Marco
dc.contributor.authorTeixeira, Manuel R
dc.contributor.authorPinto, Pedro
dc.contributor.authorSpurdle, Amanda B
dc.contributor.authorHolland, Helene
dc.contributor.authorLee, Jong Won
dc.contributor.authorLee, Min Hyuk
dc.contributor.authorLee, Jihyoun
dc.contributor.authorKim, Sung-Won
dc.contributor.authorKang, Eunyoung
dc.contributor.authorKim, Zisun
dc.contributor.authorSharma, Priyanka
dc.contributor.authorRebbeck, Timothy R
dc.contributor.authorVijai, Joseph
dc.contributor.authorRobson, Mark
dc.contributor.authorLincoln, Anne
dc.contributor.authorMusinsky, Jacob
dc.contributor.authorGaddam, Pragna
dc.contributor.authorTan, Yen Y
dc.contributor.authorBerger, Andreas
dc.contributor.authorSinger, Christian F
dc.contributor.authorLoud, Jennifer T
dc.contributor.authorGreene, Mark H
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorGlendon, Gord
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorToland, Amanda Ewart
dc.contributor.authorSenter, Leigha
dc.contributor.authorBojesen, Anders
dc.contributor.authorNielsen, Henriette Roed
dc.contributor.authorSkytte, Anne-Bine
dc.contributor.authorSunde, Lone
dc.contributor.authorJensen, Uffe Birk
dc.contributor.authorPedersen, Inge Sokilde
dc.contributor.authorKrogh, Lotte
dc.contributor.authorKruse, Torben A
dc.contributor.authorCaligo, Maria A
dc.contributor.authorYoon, Sook-Yee
dc.contributor.authorTeo, Soo-Hwang
dc.contributor.authorvon Wachenfeldt, Anna
dc.contributor.authorHuo, Dezheng
dc.contributor.authorNielsen, Sarah M
dc.contributor.authorOlopade, Olufunmilayo I
dc.contributor.authorNathanson, Katherine L
dc.contributor.authorDomchek, Susan M
dc.contributor.authorLorenchick, Christa
dc.contributor.authorJankowitz, Rachel C
dc.contributor.authorCampbell, Ian
dc.contributor.authorJames, Paul
dc.contributor.authorMitchell, Gillian
dc.contributor.authorOrr, Nick
dc.contributor.authorPark, Sue Kyung
dc.contributor.authorThomassen, Mads
dc.contributor.authorOffit, Kenneth
dc.contributor.authorCouch, Fergus J
dc.contributor.authorSimard, Jacques
dc.contributor.authorEaston, Douglas F
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorSchmutzler, Rita K
dc.contributor.authorAntoniou, Antonis C
dc.contributor.authorOttini, Laura
dc.date.accessioned2019-09-27T07:56:18Z
dc.date.available2019-09-27T07:56:18Z
dc.date.issued2017-07-10
dc.identifier.citationJ Clin Oncol. 2017;35(20):2240-2250es_ES
dc.identifier.issn0732-183Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8384
dc.description.abstractPurpose BRCA1/2 mutations increase the risk of breast and prostate cancer in men. Common genetic variants modify cancer risks for female carriers of BRCA1/2 mutations. We investigated-for the first time to our knowledge-associations of common genetic variants with breast and prostate cancer risks for male carriers of BRCA1/ 2 mutations and implications for cancer risk prediction. Materials and Methods We genotyped 1,802 male carriers of BRCA1/2 mutations from the Consortium of Investigators of Modifiers of BRCA1/2 by using the custom Illumina OncoArray. We investigated the combined effects of established breast and prostate cancer susceptibility variants on cancer risks for male carriers of BRCA1/2 mutations by constructing weighted polygenic risk scores (PRSs) using published effect estimates as weights. Results In male carriers of BRCA1/2 mutations, PRS that was based on 88 female breast cancer susceptibility variants was associated with breast cancer risk (odds ratio per standard deviation of PRS, 1.36; 95% CI, 1.19 to 1.56; P = 8.6 × 10-6). Similarly, PRS that was based on 103 prostate cancer susceptibility variants was associated with prostate cancer risk (odds ratio per SD of PRS, 1.56; 95% CI, 1.35 to 1.81; P = 3.2 × 10-9). Large differences in absolute cancer risks were observed at the extremes of the PRS distribution. For example, prostate cancer risk by age 80 years at the 5th and 95th percentiles of the PRS varies from 7% to 26% for carriers of BRCA1 mutations and from 19% to 61% for carriers of BRCA2 mutations, respectively. Conclusion PRSs may provide informative cancer risk stratification for male carriers of BRCA1/2 mutations that might enable these men and their physicians to make informed decisions on the type and timing of breast and prostate cancer risk management.es_ES
dc.description.sponsorshipWe thank Sue Healey for her contribution to CIMBA, in particular, for taking on the task of mutation classification with Olga Sinilnikova. BCFR Australia: We acknowledge Maggie Angelakos, Judi Maskiell, Gillian Dite, Helen Tsimiklis. BCFR Ontario: We thank members and participants in the Ontario Familial Breast Cancer Registry for their contributions to the study. BFBOCC-LT (Baltic Familial Breast Ovarian Cancer Consortium Lithuanian section): We acknowledge Vilius Rudaitis and Laimonas Griˇskeviˇcius. CBCS (Copenhagen Breast Cancer Study, Rigshospitalet): We thank Bent Ejlertsen Ejlertsen and Anne-Marie Gerdes for the recruitment and genetic counseling of participants. CNIO (Spanish National Cancer Centre): We thank Alicia Barroso, Rosario Alonso, and Guillermo Pita for their assistance. COH-CCGCRN (City of Hope Clinical Cancer Genomics Community Research Network): Patients were recruited for study from the City of Hope Clinical Cancer Genomics Community Research Network. CONSIT TEAM:We acknowledge Daniela Zaffaroni of the Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy; Brunella Pilato of the Istituto Nazionale Tumori “Giovanni Paolo II”, Bari, Italy; and the personnel of the Cogentech Cancer Genetic Test Laboratory, Milan, Italy. FCCC (Fox Chase Cancer Center):We thank Jo EllenWeaver and Betsy Bove, MD, for their technical support. GEMO (GeneticModifiers of cancer risk in BRCA1/2 mutation carriers):We pay a tribute to Olga M. Sinilnikova, who with Dominique Stoppa-Lyonnet, initiated and coordinated GEMO until she died on June 30, 2014, and we thank all the GEMO collaborating groups for their contribution to this study. GEMO Collaborating Centers are: Coordinating Centres, Unit´e Mixte de G´en´etique Constitutionnelle des Cancers Fr´equents, Hospices Civils de Lyon–Centre L´eon B´erard, Equipe G´en´etique du cancer du sein, Centre de Rechercheen Canc´erologie de Lyon: Olga Sinilnikova (deceased), Sylvie Mazoyer, Francesca Damiola, Laure Barjhoux, Carole Verny-Pierre, M´elanie L´eone, Nadia Boutry-Kryza, Alain Calender, Sophie Giraud; and Service de G´en´etique Oncologique, Institut Curie, Paris: Dominique Stoppa-Lyonnet, Marion Gauthier-Villars, Bruno Buecher, Claude Houdayer, Etienne Rouleau, Lisa Golmard, Agn`es Collet, Virginie Moncoutier, Muriel Belotti, Antoine de Pauw, Camille Elan, Catherine Nogues, Emmanuelle Fourme, Anne-Marie Birot; Institut Gustave Roussy, Villejuif: Brigitte Bressac-de-Paillerets, Olivier Caron, Marine Guillaud- Bataille; Centre Jean Perrin, Clermont–Ferrand: Yves-Jean Bignon, Nancy Uhrhammer; Centre L´eon B´erard, Lyon: Christine Lasset, Val´erie Bonadona, Sandrine Handallou; Centre François Baclesse, Caen: Agn`es Hardouin, Pascaline Berthet, Dominique Vaur, Laurent Castera; Institut Paoli Calmettes, Marseille: Hagay Sobol, Violaine Bourdon, Tetsuro Noguchi, Audrey Remenieras, François Eisinger; CHUArnaud-de-Villeneuve,Montpellier: Isabelle Coupier, Pascal Pujol; Centre Oscar Lambret, Lille: Jean-Philippe Peyrat, Jo¨elle Fournier, Françoise R´evillion, Philippe Vennin (deceased), Claude Adenis; Centre Paul Strauss, Strasbourg: Dani`ele Muller, Jean-Pierre Fricker; Institut Bergoni´e, Bordeaux: Emmanuelle Barouk-Simonet, Françoise Bonnet, Virginie Bubien, Nicolas Sevenet, Michel Longy; Institut Claudius Regaud, Toulouse: Christine Toulas, Rosine Guimbaud, Laurence Gladieff, Viviane Feillel; CHU Grenoble: Dominique Leroux, H´el`ene Dreyfus, Christine Rebischung, Magalie Peysselon; CHU Dijon: Fanny Coron, Laurence Faivre; CHU St-Etienne: Fabienne Prieur, Marine Lebrun, Caroline Kientz; HˆotelDieu Centre Hospitalier, Chamb´ery: Sandra Fert Ferrer; Centre Antoine Lacassagne, Nice: Marc Fr´enay; CHU Limoges: Laurence V´enat-Bouvet; CHU Nantes: Capucine Delnatte; CHU Bretonneau, Tours: Isabelle Mortemousque; Groupe Hospitalier Piti´e-Salp´etri`ere, Paris: Florence Coulet, Chrystelle Colas, Florent Soubrier, MathildeWarcoin; CHU Vandoeuvre-les- Nancy: Johanna Sokolowska, Myriam Bronner; CHU Besançon: Marie-Agn`es Collonge-Rame, Alexandre Damette; Creighton University, Omaha, NE: Henry T. Lynch, Carrie L. Snyder. G-FAST (Ghent University Hospital): B.P. is a senior clinical investigator of FWO. We acknowledge the technical support of Ilse Coeneen Brecht Crombez. HCSC (Hospital Clinico San Carlos): We acknowledge Alicia Tosar and Paula Diaque for their technical assistance. HEBCS (Helsinki Breast Cancer Study):We thank Taru A. Muranen, Carl Blomqvist, MD, Kirsimari Aaltonen, MD, Irja Erkkil¨a, RN, and Virpi Palola, RN, for their help with the HEBCS data and samples. Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON): HEBON consists of the following collaborating centers: Coordinating center: Netherlands Cancer Institute, Amsterdam: M.A. Rookus, F.B.L. Hogervorst, F.E. van Leeuwen, S. Verhoef, M.K. Schmidt, N.S. Russell, J.L. de Lange, R. Wijnands; Erasmus Medical Center: J.M. Coll´ee, A.M.W. van den Ouweland, M.J. Hooning, C. Seynaeve, C.H.M. van Deurzen, I.M. Obdeijn; Leiden University Medical Center: C.J. van Asperen, J.T. Wijnen, R.A.E.M. Tollenaar, P. Devilee, T.C.T.E.F. van Cronenburg; Radboud University NijmegenMedical Center: C.M. Kets, A.R.Mensenkamp; UniversityMedical Center Utrecht: M.G.E.M. Ausems, R.B. van der Luijt, C.C. van der Pol; Amsterdam Medical Center: C.M. Aalfs, T.A.M. van Os; Vrije Universiteit Medical Center: J.J.P. Gille, Q.Waisfisz, H.E.J. Meijers-Heijboer; University Hospital Maastricht: E.B. G´omez-Garcia, M.J. Blok; University Medical Center Groningen: J.C. Oosterwijk, A.H. van der Hout, M.J.Mourits, G.H. de Bock; The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden: H.F. Vasen; The Netherlands Comprehensive Cancer Organization (IKNL): S. Siesling, J. Verloop; The Dutch Pathology Registry (PALGA): L.I.H. Overbeek. HEBON thanks the registration teams of IKNL and PALGA for part of the data collection. HUNBOCS (Molecular Genetic Studies of Breast- and Ovarian Cancer in Hungary):We thank the Hungarian Breast and Ovarian Cancer Study Group members (Janos Papp, Aniko Bozsik, Judit Franko, Maria Balogh, Gabriella Domokos, Judit Ferenczi, Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary) and the clinicians and patients for their contributions to this study. HVH (University Hospital Vall d’Hebron): We thank the Cellex Foundation for providing research facilities and equipment. ICO (Institut Catal`a d’Oncologia): We thank the ICO Hereditary Cancer Program team led by Gabriel Capella, MD. INHERIT (INterdisciplinary HEalth Research Internal Team BReast CAncer susceptibility):We thank Martine Dumont, MD, Martine Tranchant and St´ephane Dubois for QC, sample management and skillful assistance. J.S. is Chair holder of the Canada Research Chair in Oncogenetics. J.S. and P.S. were part of the QC and Genotyping coordinating group of iCOGS and Oncoarray (BCAC and CIMBA). IPOBCS (Portuguese Oncology Institute-Porto jco.org © 2017 by American Society of Clinical Oncology Polygenic Risk Scores in Male BRCA1 and BRCA2 Mutation Carriers Downloaded from ascopubs.org by CNIO-FUND on September 27, 2019 from 193.147.150.201 Copyright © 2019 American Society of Clinical Oncology. All rights reserved. Breast Cancer Study): We thank Catarina Santos, MD, for her skillful contribution to the study. kConFab (Kathleen Cuningham Consortium for Research into Familial Breast Cancer): We thank Heather Thorne, Eveline Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the Clinical Follow Up Study for their contributions to this resource, and the many families who contribute to kConFab.Memorial Sloan Kettering Cancer Center:We acknowledge Lauren Jacobs, MD. OCGN (Ontario Cancer Genetics Network): We thank members and participants in the Ontario Cancer Genetics Network for their contributions to the study. OSUCCG (The Ohio State University Comprehensive Cancer Center): Kevin Sweet, Caroline Craven, Julia Cooper, Leigha Senter, and Michelle O’Conor were instrumental in accrual of study participants, ascertainment of medical records, and database management. SEABASS (South East Asian Breast Cancer Association Study): We thank Yip Cheng Har, Nur Aishah Mohd Taib, Phuah Sze Yee, Norhashimah Hassan, and all the research nurses, research assistants, and doctors involved in the MyBrCa Study for assistance in patient recruitment, data collection, and sample preparation. In addition, we thank Philip Iau, Sng Jen-Hwei, and Sharifah Nor Akmal for contributing samples from the Singapore Breast Cancer Study and the HUKM-HKL Study, respectively. SWE-BRCA (Swedish Breast Cancer Study): Swedish scientists participating as SWE-BRCA collaborators are: from Lund University and University Hospital: A° ke Borg, H°akan Olsson, Helena Jernstr¨om, Karin Henriksson, Katja Harbst, Maria Soller, Ulf Kristoffersson; from Gothenburg Sahlgrenska University Hospital: Anna O¨ fverholm, Margareta Nordling, Per Karlsson, Zakaria Einbeigi; from Stockholm and Karolinska University Hospital: Anna vonWachenfeldt, Annelie Liljegren, Annika Lindblom, Brita Arver, Gisela Barbany Bustinza, Johanna Rantala; from Ume°a University Hospital: Beatrice Melin, Christina Edwinsdotter Ardnor, Monica Emanuelsson; from Uppsala University: Hans Ehrencrona, Maritta Hellstr¨om Pigg, Richard Rosenquist; from Link¨oping University Hospital: Marie Stenmark-Askmalm, Sigrun Liedgren. University of Chicago: O.I.O. is an ACS Clinical Research Professor. We thank Cecilia Zvocec, Qun Niu, physicians, genetic counsellors, research nurses, and staff of the Cancer Risk Clinic for their contributions to this resource, and the many families who contribute to our program. VFCTG (Victorian Familial Cancer Trials Group):We acknowledge Geoffrey Lindeman, Marion Harris, Martin Delatycki of the Victorian Familial Cancer Trials Group.We thank Sarah Sawyer and Rebecca Driessen for assembling these data and Ella Thompson for performing all DNA amplification. © 2017 by American Society of Clinical Oncology JOURNAL OF CLINICAL ONCOLOGYes_ES
dc.language.isoenges_ES
dc.publisherAMER SOC CLINICAL ONCOLOGYes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAdult es_ES
dc.subject.meshAge Factors es_ES
dc.subject.meshAged es_ES
dc.subject.meshAged, 80 and over es_ES
dc.subject.meshBreast Neoplasms, Male es_ES
dc.subject.meshCase-Control Studies es_ES
dc.subject.meshGenetic Predisposition to Disease es_ES
dc.subject.meshGenetic Testing es_ES
dc.subject.meshGenome-Wide Association Study es_ES
dc.subject.meshHeterozygote es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPolymorphism, Single Nucleotidees_ES
dc.subject.meshProstatic Neoplasms es_ES
dc.subject.meshRisk Assessment es_ES
dc.subject.meshGenes, BRCA1 es_ES
dc.subject.meshGenes, BRCA2 es_ES
dc.subject.meshMultifactorial Inheritance es_ES
dc.subject.meshMutation es_ES
dc.titlePrediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scoreses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID28448241es_ES
dc.format.volume35es_ES
dc.format.number20es_ES
dc.format.page2240-2250es_ES
dc.identifier.doi10.1200/JCO.2016.69.4935es_ES
dc.contributor.funderAssociazione Italiana per la Ricerca sul Cancro (AIRC)es_ES
dc.contributor.funderMinistere de l'E'conomie, Innovation et Exportation du Quebec Grantes_ES
dc.contributor.funderCanadian Institutes of Health Research (CIHR)es_ES
dc.contributor.funderUnited States Department of Health & Human Services National Institutes of Health (NIH) - USAes_ES
dc.contributor.funderCancer Research UKes_ES
dc.contributor.funderNational R&D Program for Cancer Control, Ministry of Health and Welfare (Republic of Korea)es_ES
dc.contributor.funderDeutsche Krebshilfees_ES
dc.contributor.funderFondation ARCes_ES
dc.contributor.funderMinistere de l'Economie, Innovation et Exportation du Quebec Grantes_ES
dc.contributor.funderLithuania Research Council of Lithuaniaes_ES
dc.contributor.funderAECC Foundationes_ES
dc.contributor.funderFundacion Mutua Madrileñaes_ES
dc.contributor.funderUniversity of Kansas Cancer Centeres_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderAcademy of Finlandes_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderNetherlands Organization for Scientific Research (NWO)es_ES
dc.contributor.funderPink Ribbon Grantses_ES
dc.contributor.funderBBMRIes_ES
dc.contributor.funderTranscan grantes_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderMinistry of Health & Welfare, Republic of Koreaes_ES
dc.contributor.funderMalaysian Ministry of Science, Technology, and Innovation, Ministry of Higher Educationes_ES
dc.contributor.funderVictorian Cancer Agencyes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1527-7755es_ES
dc.relation.publisherversionhttps://doi.org/10.1200/JCO.2016.69.4935.es_ES
dc.identifier.journalJournal of clinical oncology : official journal of the American Society of Clinical Oncologyes_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Genética Humanaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2014-57680-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RTICC 06/0020/1060es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FISPI08/1120es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FISPI12/02585es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FISPI13/01711es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD06/0020/1051es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0036/008es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI10/01422es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI10/00748es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI13/00285es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PIE13/00022es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2009SGR290es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2014SGR364es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


Files in this item

Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-CompartirIgual 4.0 Internacional
This item is licensed under a: Atribución-NoComercial-CompartirIgual 4.0 Internacional