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dc.contributor.authorHuang, Tao
dc.contributor.authorWang, Tiange
dc.contributor.authorZheng, Yan
dc.contributor.authorEllervik, Christina
dc.contributor.authorLi, Xiang
dc.contributor.authorGao, Meng
dc.contributor.authorFang, Zhe
dc.contributor.authorChai, Jin-Fang
dc.contributor.authorAhluwalia, Tarun Veer S
dc.contributor.authorWang, Yujie
dc.contributor.authorVoortman, Trudy
dc.contributor.authorNoordam, Raymond
dc.contributor.authorFrazier-Wood, Alexis
dc.contributor.authorScholz, Markus
dc.contributor.authorSonestedt, Emily
dc.contributor.authorAkiyama, Masato
dc.contributor.authorDorajoo, Rajkumar
dc.contributor.authorZhou, Ang
dc.contributor.authorKilpeläinen, Tuomas O
dc.contributor.authorKleber, Marcus E
dc.contributor.authorCrozier, Sarah R
dc.contributor.authorGodfrey, Keith M
dc.contributor.authorLemaitre, Rozenn N
dc.contributor.authorFelix, Janine F
dc.contributor.authorShi, Yuan
dc.contributor.authorGupta, Preeti
dc.contributor.authorKhor, Chiea-Chuen
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorWang, Carol A
dc.contributor.authorTiesler, Carla M T
dc.contributor.authorThiering, Elisabeth
dc.contributor.authorStandl, Marie
dc.contributor.authorRzehak, Peter
dc.contributor.authorMarouli, Eirini
dc.contributor.authorHe, Meian
dc.contributor.authorLecoeur, Cécile
dc.contributor.authorCorella, Dolores
dc.contributor.authorLai, Chao-Qiang
dc.contributor.authorMoreno, Luis A
dc.contributor.authorPitkänen, Niina
dc.contributor.authorBoreham, Colin A
dc.contributor.authorZhang, Tao
dc.contributor.authorSaw, Seang Mei
dc.contributor.authorRidker, Paul M
dc.contributor.authorGraff, Mariaelisa
dc.contributor.authorvan Rooij, Frank J A
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorHofman, Albert
dc.contributor.authorvan Heemst, Diana
dc.contributor.authorRosendaal, Frits R
dc.contributor.authorde Mutsert, Renée
dc.contributor.authorBurkhardt, Ralph
dc.contributor.authorSchulz, Christina-Alexandra
dc.contributor.authorEricson, Ulrika
dc.contributor.authorKamatani, Yoichiro
dc.contributor.authorYuan, Jian-Min
dc.contributor.authorPower, Chris
dc.contributor.authorHansen, Torben
dc.contributor.authorSørensen, Thorkild I A
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorDelgado, Graciela
dc.contributor.authorCooper, Cyrus
dc.contributor.authorDjousse, Luc
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorJameson, Karen
dc.contributor.authorZhao, Wanting
dc.contributor.authorLiu, Jianjun
dc.contributor.authorLee, Nanette R
dc.contributor.authorRaitakari, Olli
dc.contributor.authorKähönen, Mika
dc.contributor.authorViikari, Jorma
dc.contributor.authorGrote, Veit
dc.contributor.authorLanghendries, Jean-Paul
dc.contributor.authorKoletzko, Berthold
dc.contributor.authorEscribano, Joaquin
dc.contributor.authorVerduci, Elvira
dc.contributor.authorDedoussis, George
dc.contributor.authorYu, Caizheng
dc.contributor.authorTham, Yih Chung
dc.contributor.authorLim, Blanche
dc.contributor.authorLim, Sing Hui
dc.contributor.authorFroguel, Philippe
dc.contributor.authorBalkau, Beverley
dc.contributor.authorFink, Nadia R
dc.contributor.authorVinding, Rebecca K
dc.contributor.authorSevelsted, Astrid
dc.contributor.authorBisgaard, Hans
dc.contributor.authorColtell, Oscar
dc.contributor.authorDallongeville, Jean
dc.contributor.authorGottrand, Frédéric
dc.contributor.authorPahkala, Katja
dc.contributor.authorNiinikoski, Harri
dc.contributor.authorHyppönen, Elina
dc.contributor.authorPedersen, Oluf
dc.contributor.authorMärz, Winfried
dc.contributor.authorInskip, Hazel
dc.contributor.authorJaddoe, Vincent W V
dc.contributor.authorDennison, Elaine
dc.contributor.authorWong, Tien Yin
dc.contributor.authorSabanayagam, Charumathi
dc.contributor.authorTai, E-Shyong
dc.contributor.authorMohlke, Karen L
dc.contributor.authorMackey, David A
dc.contributor.authorGruszfeld, Dariusz
dc.contributor.authorDeloukas, Panagiotis
dc.contributor.authorTucker, Katherine L
dc.contributor.authorFumeron, Frédéric
dc.contributor.authorBønnelykke, Klaus
dc.contributor.authorRossing, Peter
dc.contributor.authorEstruch, Ramon
dc.contributor.authorOrdovas, Jose M 
dc.contributor.authorArnett, Donna K
dc.contributor.authorMeirhaeghe, Aline
dc.contributor.authorAmouyel, Philippe
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorSim, Xueling
dc.contributor.authorTeo, Yik Ying
dc.contributor.authorvan Dam, Rob M
dc.contributor.authorKoh, Woon-Puay
dc.contributor.authorOrho-Melander, Marju
dc.contributor.authorLoeffler, Markus
dc.contributor.authorKubo, Michiaki
dc.contributor.authorThiery, Joachim
dc.contributor.authorMook-Kanamori, Dennis O
dc.contributor.authorMozaffarian, Dariush
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorFranco, Oscar H
dc.contributor.authorWu, Tangchun
dc.contributor.authorNorth, Kari E
dc.contributor.authorDavey Smith, George
dc.contributor.authorChavarro, Jorge E
dc.contributor.authorChasman, Daniel I
dc.contributor.authorQi, Lu
dc.date.accessioned2019-09-24T10:47:33Z
dc.date.available2019-09-24T10:47:33Z
dc.date.issued2019-09
dc.identifier.citationJAMA Netw Open. 2019; 2(9):e1910915es_ES
dc.identifier.issn2574-3805es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8372
dc.description.abstractImportance: Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations. Objective: To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis. Design, Setting, and Participants: This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleotide polymorphisms. The associations of this score with birth weight and T2D were tested in a mendelian randomization analysis using study-level data. The association of birth weight with T2D was tested using both study-level data (7 single-nucleotide polymorphisms were used as an instrumental variable) and summary-level data from the consortia (43 single-nucleotide polymorphisms were used as an instrumental variable). Data from 180 056 participants from 49 studies were included. Main Outcomes and Measures: Type 2 diabetes and glycemic traits. Results: This mendelian randomization analysis included 49 studies with 41 155 patients with T2D and 80 008 control participants from study-level data and 34 840 patients with T2D and 114 981 control participants from summary-level data. Study-level data showed that a 1-SD decrease in birth weight due to the genetic risk score was associated with higher risk of T2D among all participants (odds ratio [OR], 2.10; 95% CI, 1.69-2.61; P = 4.03 × 10-5), among European participants (OR, 1.96; 95% CI, 1.42-2.71; P = .04), and among East Asian participants (OR, 1.39; 95% CI, 1.18-1.62; P = .04). Similar results were observed from summary-level analyses. In addition, each 1-SD lower birth weight was associated with 0.189 SD higher fasting glucose concentration (β = 0.189; SE = 0.060; P = .002), but not with fasting insulin, 2-hour glucose, or hemoglobin A1c concentration. Conclusions and Relevance: In this study, a genetic predisposition to lower birth weight was associated with increased risk of T2D and higher fasting glucose concentration, suggesting genetic effects on retarded fetal growth and increased diabetes risk that either are independent of each other or operate through alterations of integrated biological mechanisms.es_ES
dc.language.isoenges_ES
dc.publisherJAMA Network es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleAssociation of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Studyes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID31539074es_ES
dc.format.volume2es_ES
dc.format.number9es_ES
dc.format.pagee1910915es_ES
dc.identifier.doi10.1001/jamanetworkopen.2019.10915es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2574-3805es_ES
dc.relation.publisherversionhttps://doi.org/10.1001/jamanetworkopen.2019.10915es_ES
dc.identifier.journalJAMA network openes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional