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dc.contributor.author | Lopez-Melgar, Beatriz | |
dc.contributor.author | Fernandez-Friera, Leticia | |
dc.contributor.author | Oliva, Belen | |
dc.contributor.author | Garcia-Ruiz, Jose M | |
dc.contributor.author | Peñalvo, Jose L | |
dc.contributor.author | Gomez-Talavera, Sandra | |
dc.contributor.author | Sanchez-Gonzalez, Javier | |
dc.contributor.author | Mendiguren, Jose M | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Fernandez-Ortiz, Antonio | |
dc.contributor.author | Sanz, Javier | |
dc.contributor.author | Fuster, Valentin | |
dc.date.accessioned | 2019-09-17T06:10:49Z | |
dc.date.available | 2019-09-17T06:10:49Z | |
dc.date.issued | 2017-07 | |
dc.identifier.citation | J Am Coll Cardiol. 2017; 70(3):301-313 | es_ES |
dc.identifier.issn | 0735-1097 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8353 | |
dc.description.abstract | BACKGROUND: Detection of subclinical atherosclerosis improves risk prediction beyond cardiovascular risk factors (CVRFs) and risk scores, but quantification of plaque burden may improve it further. Novel 3-dimensional vascular ultrasound (3DVUS) provides accurate volumetric quantification of plaque burden. OBJECTIVES: The authors evaluated associations between 3DVUS-based plaque burden and CVRFs and explored potential added value over simple plaque detection. METHODS: The authors included 3,860 (92.2%) PESA (Progression of Early Subclinical Atherosclerosis) study participants (age 45.8 ± 4.3 years; 63% men). Bilateral carotid and femoral territories were explored by 3DVUS to determine the number of plaques and territories affected, and to quantify global plaque burden defined as the sum of all plaque volumes. Linear regression and proportional odds models were used to evaluate associations of plaque burden with CVRFs and estimated 10-year cardiovascular risk. RESULTS: Plaque burden was higher in men (63.4 mm3 [interquartile range (IQR): 23.8 to 144.8 mm3] vs. 25.7 mm3 [IQR: 11.5 to 61.6 mm3] in women; p < 0.001), in the femoral territory (64 mm3 [IQR: 27.6 to 140.5 mm3] vs. 23.1 mm3 [IQR: 9.9 to 48.7 mm3] in the carotid territory; p < 0.001), and with increasing age (p < 0.001). Age, sex, smoking, and dyslipidemia were more strongly associated with femoral than with carotid disease burden, whereas hypertension and diabetes showed no territorial differences. Plaque burden was directly associated with estimated cardiovascular risk independently of the number of plaques or territories affected (p < 0.01). CONCLUSIONS: 3DVUS quantifies higher plaque burden in men, in the femoral territory, and with increasing age during midlife. Plaque burden correlates strongly with CVRFs, especially at the femoral level, and reflects estimated cardiovascular risk more closely than plaque detection alone. (Progression of Early Subclinical Atherosclerosis [PESA] Study; NCT01410318). | es_ES |
dc.description.sponsorship | The PESA study is cofunded equally by the Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain, and Banco Santander, Madrid, Spain. The study also receives funding from the Institute of Health Carlos III (PI15/02019) and the European Regional Development Fund (ERDF). The CNIC is supported by the Ministry of Economy, Industry and Competitiveness (MINECO) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). Dr. Sanchez-Gonzalez is an employee of Philips Healthcare. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Stephen J. Nicholls, MD, served as Guest Editor for this paper | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | 3-dimensional ultrasound | es_ES |
dc.subject | Carotid plaque | es_ES |
dc.subject | Femoral plaque | es_ES |
dc.subject | Plaque volume | es_ES |
dc.subject | Subclinical atherosclerosis | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Asymptomatic Diseases | es_ES |
dc.subject.mesh | Atherosclerosis | es_ES |
dc.subject.mesh | Carotid Arteries | es_ES |
dc.subject.mesh | Disease Progression | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Femoral Artery | es_ES |
dc.subject.mesh | Follow-Up Studies | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Plaque, Atherosclerotic | es_ES |
dc.subject.mesh | Prospective Studies | es_ES |
dc.subject.mesh | Reproducibility of Results | es_ES |
dc.subject.mesh | Ultrasonography | es_ES |
dc.subject.mesh | Imaging, Three-Dimensional | es_ES |
dc.title | Subclinical Atherosclerosis Burden by 3D Ultrasound in Mid-Life: The PESA Study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 28705310 | es_ES |
dc.format.volume | 70 | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | 301-313 | es_ES |
dc.identifier.doi | 10.1016/j.jacc.2017.05.033 | es_ES |
dc.contributor.funder | Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) | |
dc.contributor.funder | Banco Santander | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1558-3597 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.jacc.2017.05.033 | es_ES |
dc.identifier.journal | Journal of the American College of Cardiology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/02019 | es_ES |
dc.rights.accessRights | open access | es_ES |