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dc.contributor.authorLopez-Melgar, Beatriz 
dc.contributor.authorFernandez-Friera, Leticia 
dc.contributor.authorOliva, Belen 
dc.contributor.authorGarcia-Ruiz, Jose M 
dc.contributor.authorPenalvo, Jose L 
dc.contributor.authorGomez-Talavera, Sandra 
dc.contributor.authorSanchez-Gonzalez, Javier 
dc.contributor.authorMendiguren, Jose M
dc.contributor.authorIbanez, Borja 
dc.contributor.authorFernandez-Ortiz, Antonio 
dc.contributor.authorSanz, Javier 
dc.contributor.authorFuster, Valentin 
dc.date.accessioned2019-09-17T06:10:49Z
dc.date.available2019-09-17T06:10:49Z
dc.date.issued2017-07
dc.identifier.citationJ Am Coll Cardiol. 2017; 70(3):301-313es_ES
dc.identifier.issn0735-1097es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8353
dc.description.abstractBACKGROUND: Detection of subclinical atherosclerosis improves risk prediction beyond cardiovascular risk factors (CVRFs) and risk scores, but quantification of plaque burden may improve it further. Novel 3-dimensional vascular ultrasound (3DVUS) provides accurate volumetric quantification of plaque burden. OBJECTIVES: The authors evaluated associations between 3DVUS-based plaque burden and CVRFs and explored potential added value over simple plaque detection. METHODS: The authors included 3,860 (92.2%) PESA (Progression of Early Subclinical Atherosclerosis) study participants (age 45.8 ± 4.3 years; 63% men). Bilateral carotid and femoral territories were explored by 3DVUS to determine the number of plaques and territories affected, and to quantify global plaque burden defined as the sum of all plaque volumes. Linear regression and proportional odds models were used to evaluate associations of plaque burden with CVRFs and estimated 10-year cardiovascular risk. RESULTS: Plaque burden was higher in men (63.4 mm3 [interquartile range (IQR): 23.8 to 144.8 mm3] vs. 25.7 mm3 [IQR: 11.5 to 61.6 mm3] in women; p < 0.001), in the femoral territory (64 mm3 [IQR: 27.6 to 140.5 mm3] vs. 23.1 mm3 [IQR: 9.9 to 48.7 mm3] in the carotid territory; p < 0.001), and with increasing age (p < 0.001). Age, sex, smoking, and dyslipidemia were more strongly associated with femoral than with carotid disease burden, whereas hypertension and diabetes showed no territorial differences. Plaque burden was directly associated with estimated cardiovascular risk independently of the number of plaques or territories affected (p < 0.01). CONCLUSIONS: 3DVUS quantifies higher plaque burden in men, in the femoral territory, and with increasing age during midlife. Plaque burden correlates strongly with CVRFs, especially at the femoral level, and reflects estimated cardiovascular risk more closely than plaque detection alone. (Progression of Early Subclinical Atherosclerosis [PESA] Study; NCT01410318).es_ES
dc.description.sponsorshipThe PESA study is cofunded equally by the Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain, and Banco Santander, Madrid, Spain. The study also receives funding from the Institute of Health Carlos III (PI15/02019) and the European Regional Development Fund (ERDF). The CNIC is supported by the Ministry of Economy, Industry and Competitiveness (MINECO) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). Dr. Sanchez-Gonzalez is an employee of Philips Healthcare. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Stephen J. Nicholls, MD, served as Guest Editor for this paperes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject3-dimensional ultrasoundes_ES
dc.subjectcarotid plaquees_ES
dc.subjectfemoral plaquees_ES
dc.subjectplaque volumees_ES
dc.subjectsubclinical atherosclerosises_ES
dc.subject.meshAdult es_ES
dc.subject.meshAsymptomatic Diseases es_ES
dc.subject.meshAtherosclerosis es_ES
dc.subject.meshCarotid Arteries es_ES
dc.subject.meshDisease Progression es_ES
dc.subject.meshFemale es_ES
dc.subject.meshFemoral Artery es_ES
dc.subject.meshFollow-Up Studies es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPlaque, Atherosclerotices_ES
dc.subject.meshProspective Studies es_ES
dc.subject.meshReproducibility of Results es_ES
dc.subject.meshUltrasonography es_ES
dc.subject.meshImaging, Three-Dimensionales_ES
dc.titleSubclinical Atherosclerosis Burden by 3D Ultrasound in Mid-Life: The PESA Studyes_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID28705310es_ES
dc.format.volume70es_ES
dc.format.number3es_ES
dc.format.page301-313es_ES
dc.identifier.doi10.1016/j.jacc.2017.05.033es_ES
dc.contributor.funderCentro Nacional de Investigaciones Cardiovasculares (CNIC)es_ES
dc.contributor.funderBanco Santanderes_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1558-3597es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.jacc.2017.05.033es_ES
dc.identifier.journalJournal of the American College of Cardiologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/02019es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional