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dc.contributor.author | Fernandez-Friera, Leticia | |
dc.contributor.author | Peñalvo, Jose L | |
dc.contributor.author | Fernandez-Ortiz, Antonio | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Lopez-Melgar, Beatriz | |
dc.contributor.author | Laclaustra, Martin | |
dc.contributor.author | Oliva, Belen | |
dc.contributor.author | Mocoroa, Agustín | |
dc.contributor.author | Mendiguren, Jose M | |
dc.contributor.author | Martínez de Vega, Vicente | |
dc.contributor.author | Garcia, Laura | |
dc.contributor.author | Molina, Jesus | |
dc.contributor.author | Sanchez-Gonzalez, Javier | |
dc.contributor.author | Guzman-Martinez, Gabriela | |
dc.contributor.author | Alonso-Farto, Juan C | |
dc.contributor.author | Guallar, Eliseo | |
dc.contributor.author | Civeira, Fernando | |
dc.contributor.author | Sillesen, Henrik | |
dc.contributor.author | Pocock, Stuart | |
dc.contributor.author | Ordovas, Jose M | |
dc.contributor.author | Sanz, Gines | |
dc.contributor.author | Jimenez-Borreguero, Luis J. | |
dc.contributor.author | Fuster, Valentin | |
dc.date.accessioned | 2019-09-16T12:44:33Z | |
dc.date.available | 2019-09-16T12:44:33Z | |
dc.date.issued | 2015-06-16 | |
dc.identifier.citation | Circulation. 2015; 131(24):2104-13 | es_ES |
dc.identifier.issn | 0009-7322 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8352 | |
dc.description.abstract | BACKGROUND: Data are limited on the presence, distribution, and extent of subclinical atherosclerosis in middle-aged populations. METHODS AND RESULTS: The PESA (Progression of Early Subclinical Atherosclerosis) study prospectively enrolled 4184 asymptomatic participants 40 to 54 years of age (mean age, 45.8 years; 63% male) to evaluate the systemic extent of atherosclerosis in the carotid, abdominal aortic, and iliofemoral territories by 2-/3-dimensional ultrasound and coronary artery calcification by computed tomography. The extent of subclinical atherosclerosis, defined as presence of plaque or coronary artery calcification ≥1, was classified as focal (1 site affected), intermediate (2-3 sites), or generalized (4-6 sites) after exploration of each vascular site (right/left carotids, aorta, right/left iliofemorals, and coronary arteries). Subclinical atherosclerosis was present in 63% of participants (71% of men, 48% of women). Intermediate and generalized atherosclerosis was identified in 41%. Plaques were most common in the iliofemorals (44%), followed by the carotids (31%) and aorta (25%), whereas coronary artery calcification was present in 18%. Among participants with low Framingham Heart Study (FHS) 10-year risk, subclinical disease was detected in 58%, with intermediate or generalized disease in 36%. When longer-term risk was assessed (30-year FHS), 83% of participants at high risk had atherosclerosis, with 66% classified as intermediate or generalized. CONCLUSIONS: Subclinical atherosclerosis was highly prevalent in this middle-aged cohort, with nearly half of the participants classified as having intermediate or generalized disease. Most participants at high FHS risk had subclinical disease; however, extensive atherosclerosis was also present in a substantial number of low-risk individuals, suggesting added value of imaging for diagnosis and prevention. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01410318. | es_ES |
dc.description.sponsorship | This study was supported by a noncompetitive unrestricted grant shared equally between the CNIC and the Fundación Botín of Banco Santander. The PESA study is a noncommercial study that is independent of the healthcare and pharmaceutical industry. The CNIC is supported by the Spanish Ministry of Economy and Competitiveness and the Pro-CNIC Foundation. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Heart Association (AHA) | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Atherosclerosis | es_ES |
dc.subject | Epidemiology | es_ES |
dc.subject | Multidetector computed tomography | es_ES |
dc.subject | Population | es_ES |
dc.subject | Risk assessment | es_ES |
dc.subject | Ultrasonography | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Age Factors | es_ES |
dc.subject.mesh | Ankle Brachial Index | es_ES |
dc.subject.mesh | Aorta, Abdominal | es_ES |
dc.subject.mesh | Aortic Diseases | es_ES |
dc.subject.mesh | Aortography | es_ES |
dc.subject.mesh | Asymptomatic Diseases | es_ES |
dc.subject.mesh | Atherosclerosis | es_ES |
dc.subject.mesh | Calcinosis | es_ES |
dc.subject.mesh | Carotid Artery Diseases | es_ES |
dc.subject.mesh | Comorbidity | es_ES |
dc.subject.mesh | Coronary Angiography | es_ES |
dc.subject.mesh | Coronary Artery Disease | es_ES |
dc.subject.mesh | Disease Progression | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Femoral Artery | es_ES |
dc.subject.mesh | Follow-Up Studies | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Iliac Artery | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Multidetector Computed Tomography | es_ES |
dc.subject.mesh | Plaque, Atherosclerotic | es_ES |
dc.subject.mesh | Prevalence | es_ES |
dc.subject.mesh | Prospective Studies | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.subject.mesh | Ultrasonography | es_ES |
dc.title | Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 25882487 | es_ES |
dc.format.volume | 131 | es_ES |
dc.format.number | 24 | es_ES |
dc.format.page | 2104-13 | es_ES |
dc.identifier.doi | 10.1161/CIRCULATIONAHA.114.014310 | es_ES |
dc.contributor.funder | Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) | |
dc.contributor.funder | Banco Santander | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1524-4539 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1161/CIRCULATIONAHA.114.014310 | es_ES |
dc.identifier.journal | Circulation | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |