dc.contributor.author | Fernandez-Friera, Leticia | |
dc.contributor.author | Fuster, Valentin | |
dc.contributor.author | Lopez-Melgar, Beatriz | |
dc.contributor.author | Oliva, Belen | |
dc.contributor.author | Sanchez-Gonzalez, Javier | |
dc.contributor.author | Macias, Angel | |
dc.contributor.author | Perez-Asenjo, Braulio | |
dc.contributor.author | Zamudio, Daniel | |
dc.contributor.author | Alonso-Farto, Juan C | |
dc.contributor.author | Espana, Samuel | |
dc.contributor.author | Mendiguren, Jose M | |
dc.contributor.author | Bueno, Hector | |
dc.contributor.author | Garcia-Ruiz, Jose M | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Fernandez-Ortiz, Antonio | |
dc.contributor.author | Sanz, Javier | |
dc.date.accessioned | 2019-09-16T12:29:45Z | |
dc.date.available | 2019-09-16T12:29:45Z | |
dc.date.issued | 2019-04 | |
dc.identifier.citation | J Am Coll Cardiol. 2019; 73(12):1371-1382 | es_ES |
dc.identifier.issn | 0735-1097 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8351 | |
dc.description.abstract | BACKGROUND: Atherosclerosis is a chronic inflammatory disease, but data on arterial inflammation at early stages is limited. OBJECTIVES: The purpose of this study was to characterize vascular inflammation by hybrid 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI). METHODS: Carotid, aortic, and ilio-femoral 18F-FDG PET/MRI was performed in 755 individuals (age 40 to 54 years; 83.7% men) with known plaques detected by 2-/3-dimensional vascular ultrasound and/or coronary calcification in the PESA (Progression of Early Subclinical Atherosclerosis) study. The authors evaluated the presence, distribution, and number of arterial inflammatory foci (increased 18F-FDG uptake) and plaques with or without inflammation (coincident 18F-FDG uptake). RESULTS: Arterial inflammation was present in 48.2% of individuals (24.4% femorals, 19.3% aorta, 15.8% carotids, and 9.3% iliacs) and plaques in 90.1% (73.9% femorals, 55.8% iliacs, and 53.1% carotids). 18F-FDG arterial uptakes and plaques significantly increased with cardiovascular risk factors (p < 0.01). Coincident 18F-FDG uptakes were present in 287 of 2,605 (11%) plaques, and most uptakes were detected in plaque-free arterial segments (459 of 746; 61.5%). Plaque burden, defined by plaque presence, number, and volume, was significantly higher in individuals with arterial inflammation than in those without (p < 0.01). The number of plaques and 18F-FDG uptakes showed a positive albeit weak correlation (r = 0.25; p < 0.001). CONCLUSIONS: Arterial inflammation is highly prevalent in middle-aged individuals with known subclinical atherosclerosis. Large-scale multiterritorial PET/MRI allows characterization of atherosclerosis-related arterial inflammation and demonstrates 18F-FDG uptake in plaque-free arterial segments and, less frequently, within plaques. These findings suggest an arterial inflammatory state at early stages of atherosclerosis. (Progression of Early Subclinical Atherosclerosis [PESA]; NCT01410318). | es_ES |
dc.description.sponsorship | The PESA study is cofunded equally by the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Banco Santander. The study also receives funding from the Instituto de Salud Carlos III (PI15/02019) and the European Regional Development Fund (ERDF) “A way to make Europe.” The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Dr. Sanchez-González is an employee of Philips Healthcare. Dr. Bueno has received research funding from the Instituto de Salud Carlos III, Spain (PIE16/00021 & PI17/01799), AstraZeneca, Bristol-Myers Squibb, Janssen, and Novartis; has received consulting fees from AstraZeneca, Bayer, Bristol-Myers Squibb-Pfizer, and Novartis; and has received speaking fees or support for attending scientific meetings from AstraZeneca, Bayer, Bristol-Myers Squibb-Pfizer, Novartis, and MEDSCAPE-the heart.org. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | (18)F-FDG PET/MRI | es_ES |
dc.subject | Arterial inflammation | es_ES |
dc.subject | Plaque inflammation | es_ES |
dc.subject | Subclinical atherosclerosis | es_ES |
dc.title | Vascular Inflammation in Subclinical Atherosclerosis Detected by Hybrid PET/MRI | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 30922468 | es_ES |
dc.format.volume | 73 | es_ES |
dc.format.number | 12 | es_ES |
dc.format.page | 1371-1382 | es_ES |
dc.identifier.doi | 10.1016/j.jacc.2018.12.075 | es_ES |
dc.contributor.funder | Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) | |
dc.contributor.funder | Banco Santander | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1558-3597 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.jacc.2018.12.075 | es_ES |
dc.identifier.journal | Journal of the American College of Cardiology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Investigación Cardiovascular Traslacional Multidisciplinaria | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/02019 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI17/01799 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PIE16/00021 | es_ES |
dc.rights.accessRights | open access | es_ES |