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dc.contributor.authorObón-Santacana, Mireia
dc.contributor.authorRomaguera, Dora
dc.contributor.authorGracia-Lavedan, Esther
dc.contributor.authorMolinuevo, Amaia
dc.contributor.authorMolina-Montes, Esther 
dc.contributor.authorShivappa, Nitin
dc.contributor.authorHebert, James R
dc.contributor.authorTardón, Adonina
dc.contributor.authorCastaño-Vinyals, Gemma
dc.contributor.authorMoratalla, Ferran
dc.contributor.authorGuinó, Elisabet
dc.contributor.authorMarcos-Gragera, Rafael
dc.contributor.authorAzpiri, Mikel
dc.contributor.authorGil, Leire
dc.contributor.authorOlmedo-Requena, Rocío
dc.contributor.authorLozano-Lorca, Macarena
dc.contributor.authorAlguacil, Juan
dc.contributor.authorFernández-Villa, Tania
dc.contributor.authorMartín, Vicente
dc.contributor.authorMolina, Antonio J
dc.contributor.authorEderra, María
dc.contributor.authorMoreno-Iribas, Conchi
dc.contributor.authorPerez, Beatriz
dc.contributor.authorAragones, Nuria 
dc.contributor.authorCastello, Adela 
dc.contributor.authorHuerta, José Mª
dc.contributor.authorDierssen-Sotos, Trinidad
dc.contributor.authorGómez-Acebo, Inés
dc.contributor.authorMolina-Barceló, Ana
dc.contributor.authorPollan-Santamaria, Marina 
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorMoreno, Victor
dc.contributor.authorAmiano, Pilar
dc.date.accessioned2019-09-11T12:17:17Z
dc.date.available2019-09-11T12:17:17Z
dc.date.issued2019-06-21
dc.identifier.citationNutrients. 2019;11(6). pii: E1406.es_ES
dc.identifier.issn2072-6643es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8340
dc.description.abstractInflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60-2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99-1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26-1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent.es_ES
dc.description.sponsorshipThis research was partially funded by the public grants from the Catalan Government (2014SGR756, 2017SGR1085, 2017SGR733, SLT006/17/76), and European Regional Development Fund-ERDF, by the “AcciónTransversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León,PS09/01903-Valencia, PS09/02078-Huelva, PS09/ 01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226,PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613,PI15/00069, PI15/00914, PI15/01032, PI11/01810, PI14/01219, PI11/02213, PIE16/00049, PI17/01179, PI17-00092),by the Fundación Marqués de Valdecilla (API 10/09), by the Red Temática de Investigación del Cáncer (RTICC) del ISCIII(RD12/0036/0036), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP00310), by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation – grant GCTRA18022MORE, by the Catalan Government-Agency for Management of University and Research Grants(AGAUR) grants 2014SGR647, 2014SGR850 and 2017SGR723. Sample collection of this work was supported by the Xarxa de Bancs de Tumors de Catalunya sponsored by Pla Director d’Oncología de Catalunya (XBTC)”, Plataforma Biobancos PT13/0010/0013" and ICOBIOBANC, sponsored by the Catalan Institute of Oncology. We thank CERCA Program, Generalitat de Catalunya for institutional support. Mireia Obón-Santacana received a post-doctoral fellow from “Fundación Científica de la Asociación Española Contra el Cáncer (AECC)”.es_ES
dc.language.isoenges_ES
dc.publisherMPDIes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectMCC-Spaines_ES
dc.subjectNEACes_ES
dc.subjectantioxidantses_ES
dc.subjectbreast canceres_ES
dc.subjectcase-control studyes_ES
dc.subjectcolorectal canceres_ES
dc.subjectdietes_ES
dc.subjectdietary inflammatory indexes_ES
dc.titleDietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID31234427es_ES
dc.format.volume11es_ES
dc.format.number6es_ES
dc.format.page1406es_ES
dc.identifier.doi10.3390/nu11061406es_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderAccion Transversal del Canceres_ES
dc.contributor.funderInstituto de Investigación Marqués de Valdecillaes_ES
dc.contributor.funderJunta de Castilla y Leónes_ES
dc.contributor.funderJunta de Andaluciaes_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderRecercaixaes_ES
dc.contributor.funderGobierno Vascoes_ES
dc.contributor.funderConsejeria de Sanidad de la Region de Murciaes_ES
dc.contributor.funderFundación Científica AECCes_ES
dc.contributor.funderXarxa de Bancs de Tumors de Catalunyaes_ES
dc.contributor.funderCatalan Institute of Oncologyes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2072-6643es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/nu11061406es_ES
dc.identifier.journalNutrientses_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Epidemiología Genética y Moleculares_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1770es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/0533es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1359es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01403es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/00226es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01810es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/02213es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00488es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00265es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/01270es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00715es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00150es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/01219es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/0613es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/00069es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/00914es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/01032es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PIE16/00049es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17/01179es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17-00092es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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