Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/8340
Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)
Obón-Santacana, Mireia | Romaguera, Dora | Gracia-Lavedan, Esther | Molinuevo, Amaia | Molina-Montes, Esther CNIO | Shivappa, Nitin | Hebert, James R | Tardón, Adonina | Castaño-Vinyals, Gemma | Moratalla, Ferran | Guinó, Elisabet | Marcos-Gragera, Rafael | Azpiri, Mikel | Gil, Leire | Olmedo-Requena, Rocío | Lozano-Lorca, Macarena | Alguacil, Juan | Fernández-Villa, Tania | Martín, Vicente | Molina, Antonio J | Ederra, María | Moreno-Iribas, Conchi | Perez, Beatriz | Aragones, Nuria ISCIII | Castello, Adela ISCIII | Huerta, José Mª | Dierssen-Sotos, Trinidad | Gómez-Acebo, Inés | Molina-Barceló, Ana | Pollan-Santamaria, Marina ISCIII | Kogevinas, Manolis | Moreno, Victor | Amiano, Pilar
Nutrients. 2019;11(6). pii: E1406.
Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60-2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99-1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26-1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent.
MCC-Spain | NEAC | antioxidants | breast cancer | case-control study | colorectal cancer | diet | dietary inflammatory index
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