Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8313
Título
Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets
Autor(es)
Fecha de publicación
2018-05-01
Cita
Cold Spring Harb Perspect Med. 2018;8(5). pii: a031542.
Idioma
Inglés
Tipo de documento
journal article
Resumen
K-RAS signaling has been intensely studied for over 40 years. Yet, as of today, no drugs have been approved to treat K-RAS mutant cancers. Since the turn of the century, scientists have used genetically engineered mouse (GEM) models to reproduce K-RAS mutant cancers in a laboratory setting to elucidate those molecular events responsible for the onset and progression of these tumors and to identify suitable therapies. In this review, we outline a brief description of available GEM models for two tumor types known to be driven by K-RAS mutations: lung adenocarcinoma and pancreatic ductal adenocarcinoma. In addition, we summarize a series of studies that have used these GEM tumor models to validate, either by genetic or pharmacological approaches, the therapeutic potential of a variety of targets, with the ultimate goal of translating these results to the clinical setting.
MESH
Animals | Genes, ras | Mice | Pharmacogenetics | Signal Transduction | Adenocarcinoma of Lung | Carcinoma, Pancreatic Ductal | Disease Models, Animal | Lung Neoplasms | Pancreatic Neoplasms
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DOI
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- Nombre:
- GeneticallyEngineeredMouseMode ...
- Tamaño:
- 89.55Kb
- Formato:
- Microsoft Word 2007
- Nombre:
- GeneticallyEngineeredMouseMode ...
- Tamaño:
- 111.5Kb
- Formato:
- Microsoft Word 2007