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dc.contributor.author | Rodero, Laura | |
dc.contributor.author | Mellado, Emilia | |
dc.contributor.author | Rodriguez, A Carolina | |
dc.contributor.author | Salve, Angela | |
dc.contributor.author | Guelfand, Liliana | |
dc.contributor.author | Cahn, Pedro | |
dc.contributor.author | Cuenca-Estrella, Manuel | |
dc.contributor.author | Davel, Graciela | |
dc.contributor.author | Rodriguez-Tudela, Juan Luis | |
dc.date.accessioned | 2019-08-13T12:22:21Z | |
dc.date.available | 2019-08-13T12:22:21Z | |
dc.date.issued | 2003-11 | |
dc.identifier.citation | Antimicrob Agents Chemother. 2003 Nov;47(11):3653-6. | es_ES |
dc.identifier.issn | 0066-4804 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8247 | |
dc.description.abstract | Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S. | es_ES |
dc.description.sponsorship | We thank the Biopolymers Unit at Instituto de Salud Carlos III, Majadahonda, Madrid, Spain, for DNA sequencing and Sylvia Spitzer for providing the CNRE-1 repetitive probe. E.M. held a contract Ramon y Cajal from Ministry of Science and Technology. L.R. held a grant from PAHO and ISCIII. L.R. and E.M. contributed equally to this work. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Microbiology (ASM) | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject.mesh | Acquired Immunodeficiency Syndrome | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Amino Acid Sequence | es_ES |
dc.subject.mesh | Amino Acid Substitution | es_ES |
dc.subject.mesh | Antifungal Agents | es_ES |
dc.subject.mesh | Cloning, Molecular | es_ES |
dc.subject.mesh | Cryptococcus neoformans | es_ES |
dc.subject.mesh | Cytochrome P-450 Enzyme System | es_ES |
dc.subject.mesh | Drug Resistance, Fungal | es_ES |
dc.subject.mesh | Fluconazole | es_ES |
dc.subject.mesh | Genotype | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Meningitis, Cryptococcal | es_ES |
dc.subject.mesh | Microbial Sensitivity Tests | es_ES |
dc.subject.mesh | Molecular Sequence Data | es_ES |
dc.subject.mesh | Oxidoreductases | es_ES |
dc.subject.mesh | Plasmids | es_ES |
dc.subject.mesh | Point Mutation | es_ES |
dc.subject.mesh | Recurrence | es_ES |
dc.subject.mesh | Sterol 14-Demethylase | es_ES |
dc.title | G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 14576140 | es_ES |
dc.format.volume | 47 | es_ES |
dc.format.number | 11 | es_ES |
dc.format.page | 3653-6 | es_ES |
dc.identifier.doi | 10.1128/aac.47.11.3653-3656.2003 | es_ES |
dc.contributor.funder | Ministerio de Ciencia y Tecnología (España) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.relation.publisherversion | https://doi.org/10.1128/aac.47.11.3653-3656.2003 | es_ES |
dc.identifier.journal | Antimicrobial agents and chemotherapy | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |