Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8247
Título
G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate
Autor(es)
Rodero, Laura | Mellado, Emilia ISCIII | Rodriguez, A Carolina | Salve, Angela | Guelfand, Liliana | Cahn, Pedro | Cuenca-Estrella, Manuel ISCIII | Davel, Graciela | Rodriguez-Tudela, Juan Luis ISCIII
Fecha de publicación
2003-11
Cita
Antimicrob Agents Chemother. 2003 Nov;47(11):3653-6.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.
MESH
Acquired Immunodeficiency Syndrome | Adult | Amino Acid Sequence | Amino Acid Substitution | Antifungal Agents | Cloning, Molecular | Cryptococcus neoformans | Cytochrome P-450 Enzyme System | Drug Resistance, Fungal | Fluconazole | Genotype | Humans | Male | Meningitis, Cryptococcal | Microbial Sensitivity Tests | Molecular Sequence Data | Oxidoreductases | Plasmids | Point Mutation | Recurrence | Sterol 14-Demethylase
Versión en línea
DOI
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