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dc.contributor.authorBalsalobre-Arenas, Maria Luz 
dc.contributor.authorFerrandiz-Avellano, Maria-Jose 
dc.contributor.authorLiñares, Josefina
dc.contributor.authorTubau, Fe
dc.contributor.authorde la Campa, Adela G 
dc.date.accessioned2019-08-13T12:10:37Z
dc.date.available2019-08-13T12:10:37Z
dc.date.issued2003-07
dc.identifier.citationAntimicrob Agents Chemother. 2003 Jul;47(7):2072-81es_ES
dc.identifier.issn0066-4804es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8238
dc.description.abstractA total of 46 ciprofloxacin-resistant (Cip(r)) Streptococcus pneumoniae strains were isolated from 1991 to 2001 at the Hospital of Bellvitge. Five of these strains showed unexpectedly high rates of nucleotide variations in the quinolone resistance-determining regions (QRDRs) of their parC, parE, and gyrA genes. The nucleotide sequence of the full-length parC, parE, and gyrA genes of one of these isolates revealed a mosaic structure compatible with an interspecific recombination origin. Southern blot analysis and nucleotide sequence determinations showed the presence of an ant-like gene in the intergenic parE-parC regions of the S. pneumoniae Cip(r) isolates with high rates of variations in their parE and parC QRDRs. The ant-like gene was absent from typical S. pneumoniae strains, whereas it was present in the intergenic parE-parC regions of the viridans group streptococci (Streptococcus mitis and Streptococcus oralis). These results suggest that the viridans group streptococci are acting as donors in the horizontal transfer of fluoroquinolone resistance genes to S. pneumoniae.es_ES
dc.description.sponsorshipWe thank A. Fenoll for checking the serotypes. The technical assistance of A. Rodríguez-Bernabé is acknowledged. L.B. had a fellowship from Instituto de Salud Carlos III. This work was supported by grant BIO2002-01398 from the Ministerio de Ciencia y Tecnología and by grants 00/0258 and 01/1267 and Red Temática de Investigación Cooperativa G03/103 from Fondo de Investigación Sanitaria.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Society for Microbiology (ASM) es_ES
dc.type.hasVersionAMes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshBase Sequence es_ES
dc.subject.meshDNA Gyrase es_ES
dc.subject.meshDNA Topoisomerase IV es_ES
dc.subject.meshDNA, Intergenic es_ES
dc.subject.meshGene Transfer, Horizontal es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMolecular Sequence Data es_ES
dc.subject.meshOpen Reading Frames es_ES
dc.subject.meshRecombination, Genetic es_ES
dc.subject.meshRestriction Mapping es_ES
dc.subject.meshStreptococcus pneumoniae es_ES
dc.subject.meshViridans Streptococci es_ES
dc.titleViridans group streptococci are donors in horizontal transfer of topoisomerase IV genes to Streptococcus pneumoniaees_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID12821449es_ES
dc.format.volume47es_ES
dc.format.number7es_ES
dc.format.page2072-81es_ES
dc.identifier.doi10.1128/aac.47.7.2072-2081.2003es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderMinisterio de Ciencia y Tecnología (España) 
dc.relation.publisherversionhttps://doi.org/10.1128/aac.47.7.2072-2081.2003es_ES
dc.identifier.journalAntimicrobial agents and chemotherapyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BIO2002-01398es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/00/0258es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/01/1267es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/G03/103es_ES
dc.rights.accessRightsopen accesses_ES


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