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dc.contributor.authorGómez-Gaviro, Maria Victoria
dc.contributor.authorLovell-Badge, Robin
dc.contributor.authorFernández-Avilés, Francisco
dc.contributor.authorLara-Pezzi, Enrique 
dc.date.accessioned2019-07-30T08:33:56Z
dc.date.available2019-07-30T08:33:56Z
dc.date.issued2012-10
dc.identifier.citationJ Cardiovasc Transl Res. 2012; 5(5):618-30es_ES
dc.identifier.issn1937-5387es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7990
dc.description.abstractStem cells in adult organs reside in specialized niches that regulate their proliferation and differentiation. Investigations during the last few years have unveiled a regulatory role for blood vessels in these microenvironments. Mesenchymal stem cells (MSCs) are located surrounding capillaries in a variety of tissues and have the capacity to differentiate into different mesodermal lineages. Angiogenic progenitor cells have also been found in the adventitial layer of large vessels. In the bone marrow, endothelial cells control hematopoietic stem cell (HSC) release, and in the brain, blood vessels regulate neural stem cell (NSC) self-renewal and neurogenesis. Similarly, perivascular progenitor cells have also been found in the heart. This intimate connection between stem cells and the vasculature contributes to tissue homeostasis and repair. In this review, we focus on the regulation of stem and progenitor cells in different adult niches by blood vessels and the few mechanisms that are known to mediate this interaction.es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshBlood Vessels es_ES
dc.subject.meshCardiovascular Diseases es_ES
dc.subject.meshCell Differentiation es_ES
dc.subject.meshCell Lineage es_ES
dc.subject.meshCell Proliferation es_ES
dc.subject.meshHumans es_ES
dc.subject.meshNeovascularization, Physiologic es_ES
dc.subject.meshRegeneration es_ES
dc.subject.meshStem Cell Transplantation es_ES
dc.subject.meshStem Cells es_ES
dc.subject.meshStem Cell Niche es_ES
dc.titleThe vascular stem cell nichees_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID22644724es_ES
dc.format.volume5es_ES
dc.format.number5es_ES
dc.format.page618-30es_ES
dc.identifier.doi10.1007/s12265-012-9371-xes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1937-5395es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s12265-012-9371-xes_ES
dc.identifier.journalJournal of cardiovascular translational researches_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiacaes_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional