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dc.contributor.authorLara-Pezzi, Enrique 
dc.contributor.authorDopazo, Ana 
dc.contributor.authorManzanares, Miguel 
dc.date.accessioned2019-07-29T06:22:04Z
dc.date.available2019-07-29T06:22:04Z
dc.date.issued2012-07
dc.identifier.citationDis Model Mech. 2012; 5(4):434-43es_ES
dc.identifier.issn1754-8403es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7970
dc.description.abstractCardiovascular disease (CVD) is a major cause of mortality and hospitalization worldwide. Several risk factors have been identified that are strongly associated with the development of CVD. However, these explain only a fraction of cases, and the focus of research into the causes underlying the unexplained risk has shifted first to genetics and more recently to genomics. A genetic contribution to CVD has long been recognized; however, with the exception of certain conditions that show Mendelian inheritance, it has proved more challenging than anticipated to identify the precise genomic components responsible for the development of CVD. Genome-wide association studies (GWAS) have provided information about specific genetic variations associated with disease, but these are only now beginning to reveal the underlying molecular mechanisms. To fully understand the biological implications of these associations, we need to relate them to the exquisite, multilayered regulation of protein expression, which includes chromatin remodeling, regulatory elements, microRNAs and alternative splicing. Understanding how the information contained in the DNA relates to the operation of these regulatory layers will allow us not only to better predict the development of CVD but also to develop more effective therapies.es_ES
dc.description.sponsorshipEuropean Union [ERG-239158, ITN-289600]; Spanish Ministry of Science and Innovation [BFU2009-10016, CP08/00144, FIS PI10/01124, BFU2011-23083]; Regional Government of Madrid [S2010/BMD-2321, S2010/BMD-2315]; CNIC Translational Grant [CNIC-08-2009]; Spanish Government; Pro-CNIC Foundationes_ES
dc.language.isoenges_ES
dc.publisherCompany of Biologistes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshCardiovascular Diseases es_ES
dc.subject.meshExome es_ES
dc.subject.meshGenome, Human es_ES
dc.subject.meshGenome-Wide Association Study es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInheritance Patterns es_ES
dc.subject.meshQuantitative Trait Loci es_ES
dc.titleUnderstanding cardiovascular disease: a journey through the genome (and what we found there)es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID22730474es_ES
dc.format.volume5es_ES
dc.format.number4es_ES
dc.format.page434-43es_ES
dc.identifier.doi10.1242/dmm.009787es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1754-8411es_ES
dc.identifier.journalDisease models & mechanismses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Genómica Funcionales_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiacaes_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Genómicaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/239158/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/289600/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2011-23083es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
This item is licensed under a: Atribución-NoComercial-CompartirIgual 4.0 Internacional