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dc.contributor.author | Lara-Pezzi, Enrique | |
dc.contributor.author | Desco, Manuel | |
dc.contributor.author | Gatto, Alberto | |
dc.contributor.author | Gómez-Gaviro, María Victoria | |
dc.date.accessioned | 2019-07-26T14:22:05Z | |
dc.date.available | 2019-07-26T14:22:05Z | |
dc.date.issued | 2017-10 | |
dc.identifier.citation | Neuroscientist. 2017; 23(5):466-77 | es_ES |
dc.identifier.issn | 1073-8584 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7968 | |
dc.description.abstract | The complexity of the mammalian brain requires highly specialized protein function and diversity. As neurons differentiate and the neuronal circuitry is established, several mRNAs undergo alternative splicing and other posttranscriptional changes that expand the variety of protein isoforms produced. Recent advances are beginning to shed light on the molecular mechanisms that regulate isoform switching during neurogenesis and the role played by specific RNA binding proteins in this process. Neurogenesis and neuronal wiring were recently shown to also be regulated by RNA degradation through nonsense-mediated decay. An additional layer of regulatory complexity in these biological processes is the interplay between alternative splicing and long noncoding RNAs. Dysregulation of posttranscriptional regulation results in defective neuronal differentiation and/or synaptic connections that lead to neurodevelopmental and psychiatric disorders. | es_ES |
dc.description.sponsorship | The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Grants from the European Union (ITN-608027 "CardioNext," ITN-289600 "CardioNeT") and from the Spanish Ministry of Economy and Competitiveness (SAF2015-65722-R) to E.L-P. The CNIC is supported by the Spanish Ministry of Economy and Competitiveness and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | SAGE Publishing | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | alternative splicing | es_ES |
dc.subject | molecular neurology | es_ES |
dc.subject | molecular psychiatry | es_ES |
dc.subject | neurogenesis | es_ES |
dc.subject | noncoding RNAs | es_ES |
dc.subject | nonsense-mediated decay | es_ES |
dc.subject.mesh | Alternative Splicing | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Brain | es_ES |
dc.subject.mesh | Gene Expression | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Neurogenesis | es_ES |
dc.subject.mesh | Neurons | es_ES |
dc.subject.mesh | RNA Processing, Post-Transcriptional | es_ES |
dc.title | Neurogenesis: Regulation by Alternative Splicing and Related Posttranscriptional Processes | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 27837180 | es_ES |
dc.format.volume | 23 | es_ES |
dc.format.number | 5 | es_ES |
dc.format.page | 477 | es_ES |
dc.identifier.doi | 10.1177/1073858416678604 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1089-4098 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1177/1073858416678604 | es_ES |
dc.identifier.journal | The Neuroscientist | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiaca | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/289600/EU | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2015-65722-R | es_ES |
dc.rights.accessRights | open access | es_ES |