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dc.contributor.authorLara-Pezzi, Enrique 
dc.contributor.authorDesco, Manuel
dc.contributor.authorGatto, Alberto 
dc.contributor.authorGómez-Gaviro, María Victoria
dc.date.accessioned2019-07-26T14:22:05Z
dc.date.available2019-07-26T14:22:05Z
dc.date.issued2017-10
dc.identifier.citationNeuroscientist. 2017; 23(5):466-77es_ES
dc.identifier.issn1073-8584es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7968
dc.description.abstractThe complexity of the mammalian brain requires highly specialized protein function and diversity. As neurons differentiate and the neuronal circuitry is established, several mRNAs undergo alternative splicing and other posttranscriptional changes that expand the variety of protein isoforms produced. Recent advances are beginning to shed light on the molecular mechanisms that regulate isoform switching during neurogenesis and the role played by specific RNA binding proteins in this process. Neurogenesis and neuronal wiring were recently shown to also be regulated by RNA degradation through nonsense-mediated decay. An additional layer of regulatory complexity in these biological processes is the interplay between alternative splicing and long noncoding RNAs. Dysregulation of posttranscriptional regulation results in defective neuronal differentiation and/or synaptic connections that lead to neurodevelopmental and psychiatric disorders.es_ES
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Grants from the European Union (ITN-608027 "CardioNext," ITN-289600 "CardioNeT") and from the Spanish Ministry of Economy and Competitiveness (SAF2015-65722-R) to E.L-P. The CNIC is supported by the Spanish Ministry of Economy and Competitiveness and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherSAGEes_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectalternative splicinges_ES
dc.subjectmolecular neurologyes_ES
dc.subjectmolecular psychiatryes_ES
dc.subjectneurogenesises_ES
dc.subjectnoncoding RNAses_ES
dc.subjectnonsense-mediated decayes_ES
dc.subject.meshAlternative Splicing es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshBrain es_ES
dc.subject.meshGene Expression es_ES
dc.subject.meshHumans es_ES
dc.subject.meshNeurogenesis es_ES
dc.subject.meshNeurons es_ES
dc.subject.meshRNA Processing, Post-Transcriptional es_ES
dc.titleNeurogenesis: Regulation by Alternative Splicing and Related Posttranscriptional Processeses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID27837180es_ES
dc.format.volume23es_ES
dc.format.number5es_ES
dc.format.page477es_ES
dc.identifier.doi10.1177/1073858416678604es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1089-4098es_ES
dc.relation.publisherversionhttps://doi.org/10.1177/1073858416678604es_ES
dc.identifier.journalThe Neuroscientistes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiacaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/289600/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-65722-Res_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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