dc.contributor.author | Andres, Vicente | |
dc.date.accessioned | 2019-07-17T06:16:34Z | |
dc.date.available | 2019-07-17T06:16:34Z | |
dc.date.issued | 2014-10 | |
dc.identifier.citation | Atherosclerosis. 2014; 236(2):444-447 | es_ES |
dc.identifier.issn | 0021-9150 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7916 | |
dc.description.abstract | Signaling via both vitamin D (VitD) and the renin-angiotensin system (RAS) plays important roles in physiological processes. Evidence has mounted linking cardiovascular disease to both increased activity of the RAS and VitD deficiency. Although several studies have established functional relationships between the RAS and VitD, many aspects of their complex interaction remain unknown. In this issue of Atherosclerosis, Valcheva and colleagues show that defective VitD signaling can promote vascular damage by inducing premature senescence of smooth muscle cells due to elevated local production of angiotensin II and reactive oxygen species, and upregulation of the tumor suppressor p57(Kip2). | es_ES |
dc.description.sponsorship | Work in the author's laboratory is supported by grants from the Ministerio de Economía y Competitividad (MINECO) and Fondo Europeo de Desarrollo Regional (FEDER) (grant No. SAF2013-46663-R), Instituto de Salud Carlos III (grant No. RD12/0042/0028), European Union FP7 (Liphos, grant No. 317916), and The Progeria Research Foundation (Innovator Award 2012, and Established Investigator Award 2014). The CNIC is supported by the MINECO and Pro-CNIC Foundation. | es_ES |
dc.language.iso | eng | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Angiotensin | es_ES |
dc.subject | Cell senescence | es_ES |
dc.subject | Vascular smooth muscle cell | es_ES |
dc.subject | Vitamin D | es_ES |
dc.subject | p57 | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Cellular Senescence | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Muscle, Smooth, Vascular | es_ES |
dc.subject.mesh | Receptors, Calcitriol | es_ES |
dc.subject.mesh | Vitamin D | es_ES |
dc.title | Vitamin D puts the brakes on angiotensin II-induced oxidative stress and vascular smooth muscle cell senescence | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 25173069 | es_ES |
dc.format.volume | 236 | es_ES |
dc.format.number | 2 | es_ES |
dc.format.page | 444-7 | es_ES |
dc.identifier.doi | 10.1016/j.atherosclerosis.2014.07.031 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Progeria Research Foundation | |
dc.contributor.funder | Fundación ProCNIC | |
dc.identifier.e-issn | 1879-1484 | es_ES |
dc.identifier.journal | Atherosclerosis | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Fisiopatología Cardiovascular Molecular y Genética | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2013-46663-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0042/0028 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/317916/EU | es_ES |
dc.rights.accessRights | open access | es_ES |