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dc.contributor.authorGalindo-Albarrán, Ariel O
dc.contributor.authorLópez-Portales, Oscar H
dc.contributor.authorGutiérrez-Reyna, Darely Y
dc.contributor.authorRodríguez-Jorge, Otoniel
dc.contributor.authorSánchez-Villanueva, José Antonio
dc.contributor.authorRamírez-Pliego, Oscar
dc.contributor.authorBergon, Aurélie
dc.contributor.authorLoriod, Béatrice
dc.contributor.authorHolota, Hélène
dc.contributor.authorImbert, Jean
dc.contributor.authorHernández-Mendoza, Armando
dc.contributor.authorFerrier, Pierre
dc.contributor.authorCarrillo-de Santa Pau, Enrique
dc.contributor.authorValencia, Alfonso 
dc.contributor.authorSpicuglia, Salvatore
dc.contributor.authorSantana, M Angélica
dc.identifier.citationCell Rep. 2016;17(8):2151-2160.es_ES
dc.description.abstractTo better understand why human neonates show a poor response to intracellular pathogens, we compared gene expression and histone modification profiles of neonatal naive CD8+ T cells with that of their adult counterparts. We found that neonatal lymphocytes have a distinct epigenomic landscape associated with a lower expression of genes involved in T cell receptor (TCR) signaling and cytotoxicity and a higher expression of genes involved in the cell cycle and innate immunity. Functional studies corroborated that neonatal CD8+ T cells are less cytotoxic, transcribe antimicrobial peptides, and produce reactive oxygen species. Altogether, our results show that neonatal CD8+ T cells have a specific genetic program biased toward the innate immune response. These findings will contribute to better diagnosis and management of the neonatal immune response.es_ES
dc.description.sponsorshipThis project was specifically supported by a joint EcosNord-Anuies-SEP-Con-acyt project (M11S01). Work in the M.A.S. laboratory is supported by grantsfrom Consejo Nacional de Ciencia y Tecnologı ́a(CONACYT; CB-2011-01168182) and Programa de Mejoramiento del Profesorado (PROMEPSI-UAEM/13/342). Work in the S.S. laboratory is supported by recurrent fundingfrom the Inserm and Aix-Marseille University and by specific grants from theEuropean Union’s FP7 Program (agreement 282510-BLUEPRINT), the Associ-ation pour la Recherche contre le Cancer (ARC) (project SFI20111203756), andthe Aix-Marseille initiative d’excelence (A*MIDEX) project ANR-11-IDEX-0001-02. We thank Centro Estatal de la Transfusio ́n Sanguı ́nea in Cuernavaca for thedonation of leukocyte concentrates and the mothers and babies of HospitalGeneral Parres in Cuernavaca for the donation of cord blood. This study makesuse of data generated by the Blueprint and Roadmap consortia. A full list of theinvestigators who contributed to the generation of the data is availablefromwww.blueprint-epigenome.euand Funding for the Blueprint project was provided by the European Union’sSeventh Framework Program (FP7/2007-2013) under grant agreement282510 – BLUEPRINT. The Roadmap consortium is financed by the NIH. Weare grateful to Professor C.I. Pogson for critical reading of the manuscript.es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectT lymphocytees_ES
dc.subjecthuman immunityes_ES
dc.subjectimmune responsees_ES
dc.subject.meshAdult es_ES
dc.subject.meshCD8-Positive T-Lymphocytes es_ES
dc.subject.meshCytotoxicity, Immunologices_ES
dc.subject.meshEpigenesis, Genetices_ES
dc.subject.meshGene Expression Profiling es_ES
dc.subject.meshGene Expression Regulation, Developmental es_ES
dc.subject.meshHumans es_ES
dc.subject.meshImmunity, Innate es_ES
dc.subject.meshInfant, Newborn es_ES
dc.subject.meshTranscription Factors es_ES
dc.titleCD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Responsees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.contributor.funderConsejo Nacional de Ciencia y Tecnologia (CONACYT)es_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderPrograma de Mejoramiento del Profesoradoes_ES
dc.contributor.funderAix-Marseille Universityes_ES
dc.contributor.funderAssociation pour la Recherche contre le Cancer (ARC)es_ES
dc.identifier.journalCell reportses_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Biología Computacional Estructurales_ES

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