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dc.contributor.author | Leon-Espinosa, Gonzalo | |
dc.contributor.author | Sanchez-Ruiloba, Lucia | |
dc.contributor.author | Perez-Rodriguez, Andrea | |
dc.contributor.author | Gragera, Teresa | |
dc.contributor.author | Martinez, Natalia | |
dc.contributor.author | Hernandez, Silvia | |
dc.contributor.author | Anta-Felez, Berta | |
dc.contributor.author | Calero, Olga | |
dc.contributor.author | Garcia-Dominguez, Carlota A | |
dc.contributor.author | Dura, Lara M | |
dc.contributor.author | Peña-Jiménez, Daniel | |
dc.contributor.author | Castro, Judith | |
dc.contributor.author | Zarich-Dimitrievich, Natasha | |
dc.contributor.author | Sánchez-Gómez, Pilar | |
dc.contributor.author | Calero, Miguel | |
dc.contributor.author | Iglesias, Teresa | |
dc.contributor.author | Oliva-Martinez, Jose Luis | |
dc.contributor.author | Rojas-Cabañeros, Jose Maria | |
dc.date.accessioned | 2019-07-12T08:31:12Z | |
dc.date.available | 2019-07-12T08:31:12Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | PLoS One. 2014 Dec 16;9(12):e114837 | es_ES |
dc.identifier.issn | 1932-6203 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7899 | |
dc.description.abstract | The Shoc2 protein has been implicated in the positive regulation of the Ras-ERK pathway by increasing the functional binding interaction between Ras and Raf, leading to increased ERK activity. Here we found that Shoc2 overexpression induced sustained ERK phosphorylation, notably in the case of EGF stimulation, and Shoc2 knockdown inhibited ERK activation. We demonstrate that ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of EGF, a stimulus that induces proliferation rather than differentiation in these cells. Finally, Shoc2 depletion reduces both NGF-induced neurite outgrowth and ERK activation in PC12 cells. Our data indicate that Shoc2 is essential to modulate the Ras-ERK signaling outcome in cell differentiation processes involved in neurite outgrowth. | es_ES |
dc.description.sponsorship | This work was supported by FIS grant (PI10/00815) to JLO; CIBERNED to MC; SAF2008-01951, Comunidad Autónoma de Madrid (CAM) S-SAL-0202-2006-01 and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) to TI; FIS grant PI12/00775 and ISCIII-RETIC (Red Temática de Investigación Cooperativa en Cáncer) RD12/0036/0027 from the Instituto de Salud Carlos III to PSG; and FIS grants (PI09/0562 and PI13/00703), ISCIII-RETIC (RD06/0020/0003 and RD12/0036/0021), and the Spanish Association Against Cancer (AECC) to JMR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science (PLOS) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Cell Line, Tumor | es_ES |
dc.subject.mesh | Enzyme Activation | es_ES |
dc.subject.mesh | Epidermal Growth Factor | es_ES |
dc.subject.mesh | Extracellular Signal-Regulated MAP Kinases | es_ES |
dc.subject.mesh | HEK293 Cells | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Intracellular Signaling Peptides and Proteins | es_ES |
dc.subject.mesh | MAP Kinase Signaling System | es_ES |
dc.subject.mesh | Neurites | es_ES |
dc.subject.mesh | PC12 Cells | es_ES |
dc.subject.mesh | Phosphorylation | es_ES |
dc.subject.mesh | RNA Interference | es_ES |
dc.subject.mesh | RNA, Small Interfering | es_ES |
dc.subject.mesh | Rats | es_ES |
dc.subject.mesh | ras Proteins | es_ES |
dc.title | Shoc2/Sur8 Protein Regulates Neurite Outgrowth | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 25514808 | es_ES |
dc.format.volume | 9 | es_ES |
dc.format.number | 12 | es_ES |
dc.format.page | e114837 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0114837 | es_ES |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España) | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1932-6203 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0114837 | es_ES |
dc.identifier.journal | PLoS ONE | es_ES |
dc.repisalud.centro | ISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC) | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI10/00815 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2008-01951 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/S-SAL-0202-2006-01 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00775 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0036/0027 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/0562 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI13/00703 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD06/0020/0003 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0036/0021 | es_ES |
dc.rights.accessRights | open access | es_ES |