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dc.contributor.authorJuan, David
dc.contributor.authorPerner, Juliane
dc.contributor.authorCarrillo de Santa Pau, Enrique
dc.contributor.authorMarsili, Simone
dc.contributor.authorOchoa, David
dc.contributor.authorChung, Ho-Ryun
dc.contributor.authorVingron, Martin
dc.contributor.authorRico, Daniel 
dc.contributor.authorValencia, Alfonso 
dc.date.accessioned2019-07-11T09:04:19Z
dc.date.available2019-07-11T09:04:19Z
dc.date.issued2016-02-09
dc.identifier.citationCell Rep. 2016;14(5):1246-1257es_ES
dc.identifier.issn22111247es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7890
dc.description.abstractEpigenetic communication through histone and cytosine modifications is essential for gene regulation and cell identity. Here, we propose a framework that is based on a chromatin communication model to get insight on the function of epigenetic modifications in ESCs. The epigenetic communication network was inferred from genome-wide location data plus extensive manual annotation. Notably, we found that 5-hydroxymethylcytosine (5hmC) is the most-influential hub of this network, connecting DNA demethylation to nucleosome remodeling complexes and to key transcription factors of pluripotency. Moreover, an evolutionary analysis revealed a central role of 5hmC in the co-evolution of chromatin-related proteins. Further analysis of regions where 5hmC co-localizes with specific interactors shows that each interaction points to chromatin remodeling, stemness, differentiation, or metabolism. Our results highlight the importance of cytosine modifications in the epigenetic communication of ESCs.es_ES
dc.description.sponsorshipWe thank Prof. Stunnenberg and all members of BLUEPRINT Consortium forcritical comments. The research leading to these results has received fundingfrom the European Union’s Seventh Framework Programme (FP7/2007-2013)under grant agreement number 282510 (BLUEPRINT)es_ES
dc.language.isoenges_ES
dc.publisherCELL PRESSes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.mesh5-Methylcytosine es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshChromatin es_ES
dc.subject.meshCytosine es_ES
dc.subject.meshMice es_ES
dc.subject.meshMouse Embryonic Stem Cells es_ES
dc.subject.meshMultiprotein Complexes es_ES
dc.subject.meshSignal Transduction es_ES
dc.subject.meshEpigenesis, Genetices_ES
dc.subject.meshEvolution, Moleculares_ES
dc.titleEpigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID26832418es_ES
dc.format.volume14es_ES
dc.format.number5es_ES
dc.format.page1246-1257es_ES
dc.identifier.doi10.1016/j.celrep.2016.01.008es_ES
dc.contributor.funderEuropean Union's Seventh Framework Programmees_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2211-1247es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.celrep.2016.01.008.es_ES
dc.identifier.journalCell reportses_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Biología Computacional Estructurales_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/282510es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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