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dc.contributor.authorCossio, Itziar 
dc.contributor.authorLucas, Daniel
dc.contributor.authorHidalgo, Andrés 
dc.date.accessioned2019-07-03T14:11:16Z
dc.date.available2019-07-03T14:11:16Z
dc.date.issued2019-05
dc.identifier.citationBlood. 2019; 133(20):2140-2148es_ES
dc.identifier.issn0006-4971es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7849
dc.description.abstractThe niche that supports hematopoietic stem and progenitor cells (HSPCs) in the bone marrow is a highly dynamic structure. It maintains core properties of HSPCs in the steady state, and modulates their proliferation and differentiation in response to changing physiological demands or pathological insults. The dynamic and environment-sensing properties of the niche are shared by the innate immune system. Thus, it is not surprising that innate immune cells, including macrophages and neutrophils, are now recognized as important regulators of the hematopoietic niche and, ultimately, of the stem cells from which they derive. This review synthesizes emerging concepts on niche regulation by immune cells, with a particular emphasis on neutrophils. We argue that the unique developmental, circadian, and migratory properties of neutrophils underlie their critical contributions as regulators of the hematopoietic niche.es_ES
dc.description.sponsorshipThis work was supported in part by SAF2015-65607-R and Fondo Europeo de Desarrollo Regional (FEDER) (A.H.); Ministerio de Ciencia, Innovacion y Universidades (MCIU) for fellowship BES-2014-068915 (I.C.); and R01 HL136529-01 from the National Institutes of Health, National Heart, Lung, and Blood Institute (D.L.). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) was supported by the MCIU and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MCIU award SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherAmerican Society of Hematology (ASH) es_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleNeutrophils as regulators of the hematopoietic nichees_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID30898859es_ES
dc.format.volume133es_ES
dc.format.number20es_ES
dc.format.page2140-2148es_ES
dc.identifier.doi10.1182/blood-2018-10-844571es_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.contributor.funderNational Institutes of Health (United States)
dc.contributor.funderFundación ProCNIC
dc.description.peerreviewedes_ES
dc.embargo.terms2020-05-01es_ES
dc.identifier.e-issn1528-0020es_ES
dc.relation.publisherversionhttps://doi.org/10.1182/blood-2018-10-844571es_ES
dc.identifier.journalBloodes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-65607-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BES-2014-068915es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional