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dc.contributor.authorÁlvaro, Edurne
dc.contributor.authorCano, Juana M
dc.contributor.authorGarcía, Juan L
dc.contributor.authorBrandáriz, Lorena
dc.contributor.authorOlmedillas-López, Susana
dc.contributor.authorArriba, María
dc.contributor.authorRueda, Daniel
dc.contributor.authorRodríguez, Yolanda
dc.contributor.authorCañete, Ángel
dc.contributor.authorArribas, Julia
dc.contributor.authorInglada Perez, Lucia 
dc.contributor.authorPérez, Jessica
dc.contributor.authorGómez, Carlos
dc.contributor.authorGarcía-Arranz, Mariano
dc.contributor.authorGarcía-Olmo, Damián
dc.contributor.authorGoel, Ajay
dc.contributor.authorUrioste, Miguel 
dc.contributor.authorGonzález-Sarmiento, Rogelio
dc.contributor.authorPerea, José
dc.date.accessioned2019-07-01T11:44:16Z
dc.date.available2019-07-01T11:44:16Z
dc.date.issued2019-02-22
dc.identifier.citationInt J Mol Sci. 2019;20(4). pii: E968.es_ES
dc.identifier.issn1422-0067es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7826
dc.description.abstractOur aim was to characterize and validate that the location and age of onset of the tumor are both important criteria to classify colorectal cancer (CRC). We analyzed clinical and molecular characteristics of early-onset CRC (EOCRC) and late-onset CRC (LOCRC), and we compared each tumor location between both ages-of-onset. In right-sided colon tumors, early-onset cases showed extensive Lynch syndrome (LS) features, with a relatively low frequency of chromosomal instability (CIN), but a high CpG island methylation phenotype. Nevertheless, late-onset cases showed predominantly sporadic features and microsatellite instability cases due to BRAF mutations. In left colon cancers, the most reliable clinical features were the tendency to develop polyps as well as multiple primary CRC associated with the late-onset subset. Apart from the higher degree of CIN in left-sided early-onset cancers, differential copy number alterations were also observed. Differences among rectal cancers showed that early-onset rectal cancers were diagnosed at later stages, had less association with polyps, and more than half of them were associated with a familial LS component. Stratifying CRC according to both location and age-of-onset criteria is meaningful, not only because it correlates the resulting categories with certain molecular bases, but with the confirmation across larger studies, new therapeutical algorithms could be defined according to this subclassification.es_ES
dc.description.sponsorshipWe thank Ron Hartong for his help with the English revision of this article.This work was funded by Project PI10/0683 and PI13/0127 and PI16/01650 to J.P, and PI16/01920 to R.G.S, and PI17/01233 to D.G-O from the Spanish Ministry of Health and Consumer Affairs, and co-funded by the European Regional Development Fund (FEDER); and supported by grants R01 CA72851, CA18172, CA184792, and U01 CA187956 from the National Cancer Institute, National Institutes of Health to Ajay Goel.es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCpG island methylator phenotypees_ES
dc.subjectChromosomal instabilityes_ES
dc.subjectEarly-onset colorectal canceres_ES
dc.subjectLate-onset colorectal canceres_ES
dc.subjectMicrosatellite instabilityes_ES
dc.subjectTumor location.es_ES
dc.subject.meshAge of Onset es_ES
dc.subject.meshColorectal Neoplasms es_ES
dc.subject.meshGene Dosage es_ES
dc.subject.meshHumans es_ES
dc.titleClinical and Molecular Comparative Study of Colorectal Cancer Based on Age-of-onset and Tumor Location: Two Main Criteria for Subclassifying Colorectal Canceres_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID30813366es_ES
dc.format.volume20es_ES
dc.format.number4es_ES
dc.format.page968es_ES
dc.identifier.doi10.3390/ijms20040968es_ES
dc.contributor.funderMinisterio de Sanidad y Consumo (España) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderNational Institutes of Health (Estados Unidos) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1422-0067es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms20040968.es_ES
dc.identifier.journalInternational journal of molecular scienceses_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Unidades técnicas::Unidad Clínica de Cáncer Familiares_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI10/0683es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI13/0127es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI16/01650es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI16/01920es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17/01233es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional