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dc.contributor.authorGarcía-Pérez, Javier 
dc.contributor.authorPollan-Santamaria, Marina 
dc.contributor.authorPerez-Gomez, Beatriz 
dc.contributor.authorGonzalez-Sanchez, Mario 
dc.contributor.authorCortes-Barragan, Rosana 
dc.contributor.authorMaqueda-Blasco, Jeronimo 
dc.contributor.authorGonzález-Galarzo, María Carmen
dc.contributor.authorAlba, Miguel Ángel
dc.contributor.authorvan der Haar, Rudolf
dc.contributor.authorCasas, Silvia
dc.contributor.authorVicente, Cándida
dc.contributor.authorMedina, Pilar
dc.contributor.authorEderra, María
dc.contributor.authorSantamariña, Carmen
dc.contributor.authorMoreno, María Pilar
dc.contributor.authorCasanova, Francisco
dc.contributor.authorPedraz-Pingarrón, Carmen
dc.contributor.authorMoreo, Pilar
dc.contributor.authorAscunce, Nieves
dc.contributor.authorGarcía, Montse
dc.contributor.authorSalas-Trejo, Dolores
dc.contributor.authorSánchez-Contador, Carmen
dc.contributor.authorLlobet, Rafael
dc.contributor.authorLope Carvajal, Virginia 
dc.date.accessioned2019-06-28T08:13:57Z
dc.date.available2019-06-28T08:13:57Z
dc.date.issued2017
dc.identifier.citationEnviron Res. 2017 Nov;159:355-361es_ES
dc.identifier.issn0013-9351es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7818
dc.description.abstractINTRODUCTION: High mammographic density is one of the main risk factors for breast cancer. Although several occupations have been associated with breast cancer, there are no previous occupational studies exploring the association with mammographic density. Our objective was to identify occupations associated with high mammographic density in Spanish female workers. METHODS: We conducted a population-based cross-sectional study of occupational determinants of high mammographic density in Spain, based on 1476 women, aged 45-68 years, recruited from seven screening centers within the Spanish Breast Cancer Screening Program network. Reproductive, family, personal, and occupational history data were collected. The latest occupation of each woman was collected and coded according to the 1994 National Classification of Occupations. Mammographic density was assessed from the cranio-caudal mammogram of the left breast using a semi-automated computer-assisted tool. Association between mammographic density and occupation was evaluated by using mixed linear regression models, using log-transformed percentage of mammographic density as dependent variable. Models were adjusted for age, body mass index, menopausal status, parity, smoking, alcohol intake, educational level, type of mammography, first-degree relative with breast cancer, and hormonal replacement therapy use. Screening center and professional reader were included as random effects terms. RESULTS: Mammographic density was higher, although non-statistically significant, among secondary school teachers (eβ = 1.41; 95%CI = 0.98-2.03) and nurses (eβ = 1.23; 95%CI = 0.96-1.59), whereas workers engaged in the care of people (eβ = 0.81; 95%CI = 0.66-1.00) and housewives (eβ = 0.87; 95%CI = 0.79-0.95) showed an inverse association with mammographic density. A positive trend for every 5 years working as secondary school teachers was also detected (p-value = 0.035). CONCLUSIONS: Nurses and secondary school teachers were the occupations with the highest mammographic density in our study, showing the latter a positive trend with duration of employment. Future studies are necessary to confirm if these results are due to chance or are the result of a true association whose causal hypothesis is, for the moment, unknown.es_ES
dc.description.sponsorshipThis study was funded by Strategic Action of Intramural Health (Acción Estratégica de Salud Intramural - AESI PI15CIII/00013); the Scientific Foundation of the Spanish Association Against Cancer (Fundación Científica de la Asociación Española Contra el Cáncer (AECC) – EVP-1178/14); the Research Grant FIS PI060386 & PS09/790 from Spain’s Health Research Fund (Fondo de Investigación Sanitaria); the EPY 1306/06 Collaboration Agreement between Astra-Zeneca and the Carlos III Institute of Health; and a grant from the Spanish Federation of Breast Cancer patients (FECMA 485 EPY 1170-10).es_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionSMURes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBreast canceres_ES
dc.subjectDDM-Occupes_ES
dc.subjectMammographic densityes_ES
dc.subjectNurseses_ES
dc.subjectOccupationes_ES
dc.subjectSchool teacherses_ES
dc.subject.meshAged es_ES
dc.subject.meshCross-Sectional Studies es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLinear Models es_ES
dc.subject.meshMammography es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshOccupations es_ES
dc.subject.meshSpain es_ES
dc.subject.meshBreast Density es_ES
dc.titleOccupation and mammographic density: A population-based study (DDM-Occup)es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID28843166es_ES
dc.format.volume159es_ES
dc.format.page355-361es_ES
dc.identifier.doi10.1016/j.envres.2017.08.028es_ES
dc.contributor.funderAsociación Española Contra el Cáncer 
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1096-0953es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.envres.2017.08.028es_ES
dc.identifier.journalEnvironmental researches_ES
dc.repisalud.centroISCIII::Escuela Nacional de Medicina del Trabajoes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiología
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15CIII/00013es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/EVP-1178/14es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI060386es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/790es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/EPY1306/06es_ES
dc.rights.accessRightsopen accesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional