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dc.contributor.authorGarcía-Pérez, Javier 
dc.contributor.authorLopez-Abente, Gonzalo 
dc.contributor.authorGomez-Barroso, Diana 
dc.contributor.authorMorales-Piga, Antonio 
dc.contributor.authorRomaguera, Elena Pardo
dc.contributor.authorTamayo, Ibon
dc.contributor.authorFernandez-Navarro, Pablo L 
dc.contributor.authorRamis, Rebeca 
dc.date.accessioned2019-06-28T07:47:50Z
dc.date.available2019-06-28T07:47:50Z
dc.date.issued2015-07
dc.identifier.citationEnviron Res. 2015 Jul;140:542-53.es_ES
dc.identifier.issn0013-9351es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7817
dc.description.abstractBACKGROUND: Few risk factors for the childhood leukemia are well established. While a small fraction of cases of childhood leukemia might be partially attributable to some diseases or ionizing radiation exposure, the role of industrial and urban pollution also needs to be assessed. OBJECTIVES: To ascertain the possible effect of residential proximity to both industrial and urban areas on childhood leukemia, taking into account industrial groups and toxic substances released. METHODS: We conducted a population-based case-control study of childhood leukemia in Spain, covering 638 incident cases gathered from the Spanish Registry of Childhood Tumors and for those Autonomous Regions with 100% coverage (period 1990-2011), and 13,188 controls, individually matched by year of birth, sex, and autonomous region of residence. Distances were computed from the respective subject's residences to the 1068 industries and the 157 urban areas with ≥10,000 inhabitants, located in the study area. Using logistic regression, odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance to industrial and urban pollution sources were calculated, with adjustment for matching variables. RESULTS: Excess risk of childhood leukemia was observed for children living near (≤2.5 km) industries (OR=1.31; 95%CI=1.03-1.67) - particularly glass and mineral fibers (OR=2.42; 95%CI=1.49-3.92), surface treatment using organic solvents (OR=1.87; 95%CI=1.24-2.83), galvanization (OR=1.86; 95%CI=1.07-3.21), production and processing of metals (OR=1.69; 95%CI=1.22-2.34), and surface treatment of metals (OR=1.62; 95%CI=1.22-2.15) - , and urban areas (OR=1.36; 95%CI=1.02-1.80). CONCLUSIONS: Our study furnishes some evidence that living in the proximity of industrial and urban sites may be a risk factor for childhood leukemia.es_ES
dc.description.sponsorshipThis study was funded by Spain’s Health Research Fund (Fondode Investigación Sanitaria–FIS 12/01416 and FIS CP11/00112).es_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionSMURes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCase–control studyes_ES
dc.subjectChildhood leukemiaes_ES
dc.subjectIndustrial pollutiones_ES
dc.subjectResidential proximityes_ES
dc.subjectUrban pollutiones_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshCase-Control Studies es_ES
dc.subject.meshChild es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLeukemia es_ES
dc.subject.meshMale es_ES
dc.subject.meshSpain es_ES
dc.subject.meshResidence Characteristics es_ES
dc.subject.meshUrban Health es_ES
dc.titleChildhood leukemia and residential proximity to industrial and urban siteses_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID26025512es_ES
dc.format.volume140es_ES
dc.format.page542-53es_ES
dc.identifier.doi10.1016/j.envres.2015.05.014es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1096-0953es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.envres.2015.05.014es_ES
dc.identifier.journalEnvironmental researches_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.centroISCIII::Instituto de Investigación de Enfermedades Rarases_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FIS12/01416es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FISCP11/00112es_ES
dc.rights.accessRightsopen accesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional