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dc.contributor.authorGarcia-Saenz, Ariadna
dc.contributor.authorSánchez de Miguel, Alejandro
dc.contributor.authorEspinosa, Ana
dc.contributor.authorValentin, Antonia
dc.contributor.authorAragones, Nuria 
dc.contributor.authorLlorca, Javier
dc.contributor.authorAmiano, Pilar
dc.contributor.authorMartín Sánchez, Vicente
dc.contributor.authorGuevara, Marcela
dc.contributor.authorCapelo, Rocío
dc.contributor.authorTardón, Adonina
dc.contributor.authorPeiró-Perez, Rosana
dc.contributor.authorJimenez-Moleon, Jose J.
dc.contributor.authorRoca-Barceló, Aina
dc.contributor.authorPerez-Gomez, Beatriz 
dc.contributor.authorDierssen-Sotos, Trinidad
dc.contributor.authorFernández-Villa, Tania
dc.contributor.authorMoreno-Iribas, Conchi
dc.contributor.authorMoreno, Victor
dc.contributor.authorGarcía-Pérez, Javier 
dc.contributor.authorCastaño-Vinyals, Gemma
dc.contributor.authorPollan-Santamaria, Marina 
dc.contributor.authorAubé, Martin
dc.contributor.authorKogevinas, Manolis
dc.date.accessioned2019-06-26T08:30:46Z
dc.date.available2019-06-26T08:30:46Z
dc.date.issued2018
dc.identifier.citationEnviron Health Perspect. 2018 Apr 23;126(4):047011.es_ES
dc.identifier.issn0091-6765es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7801
dc.description.abstractBACKGROUND: Night shift work, exposure to light at night (ALAN) and circadian disruption may increase the risk of hormone-dependent cancers. OBJECTIVES: We evaluated the association of exposure to ALAN during sleeping time with breast and prostate cancer in a population based multicase-control study (MCC-Spain), among subjects who had never worked at night. We evaluated chronotype, a characteristic that may relate to adaptation to light at night. METHODS: We enrolled 1,219 breast cancer cases, 1,385 female controls, 623 prostate cancer cases, and 879 male controls from 11 Spanish regions in 2008-2013. Indoor ALAN information was obtained through questionnaires. Outdoor ALAN was analyzed using images from the International Space Station (ISS) available for Barcelona and Madrid for 2012-2013, including data of remotely sensed upward light intensity and blue light spectrum information for each geocoded longest residence of each MCC-Spain subject. RESULTS: Among Barcelona and Madrid participants with information on both indoor and outdoor ALAN, exposure to outdoor ALAN in the blue light spectrum was associated with breast cancer [adjusted odds ratio (OR) for highest vs. lowest tertile, OR=1.47; 95% CI: 1.00, 2.17] and prostate cancer (OR=2.05; 95% CI: 1.38, 3.03). In contrast, those exposed to the highest versus lowest intensity of outdoor ALAN were more likely to be controls than cases, particularly for prostate cancer. Compared with those who reported sleeping in total darkness, men who slept in "quite illuminated" bedrooms had a higher risk of prostate cancer (OR=2.79; 95% CI: 1.55, 5.04), whereas women had a slightly lower risk of breast cancer (OR=0.77; 95% CI: 0.39, 1.51). CONCLUSION: Both prostate and breast cancer were associated with high estimated exposure to outdoor ALAN in the blue-enriched light spectrum. https://doi.org/10.1289/EHP1837.es_ES
dc.description.sponsorshipThe study was partially funded by the Accion Transversal del Cancer, approved by the Spanish Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/01662-Granada, PI11/01889-FEDER, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI14/0613), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL [the ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)], by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the Catalan Government–Agency for Management of University and Research Grants (AGAUR) grants 2014SGR647 and 2014SGR850, by the Fundación Caja de Ahorros de Asturias, and by the University of Oviedo. ISGlobal is a member of the Centres de Recerca de Catalunya (CERCA) Programme, Generalitat de Catalunya.es_ES
dc.language.isoenges_ES
dc.publisherNational Institute of Environmental Health Sciences (NIEHS) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAdult es_ES
dc.subject.meshAged es_ES
dc.subject.meshAged, 80 and over es_ES
dc.subject.meshBreast Neoplasms es_ES
dc.subject.meshCase-Control Studies es_ES
dc.subject.meshCircadian Rhythm es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshIncidence es_ES
dc.subject.meshLight es_ES
dc.subject.meshLighting es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshProstatic Neoplasms es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshSpain es_ES
dc.subject.meshYoung Adult es_ES
dc.titleEvaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study)es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID29687979es_ES
dc.format.volume126es_ES
dc.format.number4es_ES
dc.format.page047011es_ES
dc.identifier.doi10.1289/EHP1837es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderFundación Marqués de Valdecilla 
dc.contributor.funderInternational Cancer Genome Consortium 
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderRed Temática de Investigación Cooperativa en Cáncer (RTICC) (España) 
dc.contributor.funderJunta de Castilla y León (España) 
dc.contributor.funderGeneralitat Valenciana (España) 
dc.contributor.funderRegional Government of Andalusia (España) 
dc.contributor.funderGobierno de la Región de Murcia (España) 
dc.contributor.funderUnión Europea. Comisión Europea 
dc.contributor.funderAsociación Española Contra el Cáncer 
dc.contributor.funderGovernment of Catalonia (España) 
dc.contributor.funderAgència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) 
dc.contributor.funderFundación Caja de Ahorros de Asturias 
dc.contributor.funderUniversity of Oviedo (España) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1552-9924es_ES
dc.relation.publisherversionhttps://doi.org/10.1289/EHP1837es_ES
dc.identifier.journalEnvironmental health perspectiveses_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1770es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/0533es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1359es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/00773es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01286es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01903es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/02078es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01662es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01889es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/02213es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00488es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00265es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/01270es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00715es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/0613es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/API10/09es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0036/0036es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/LE22A10-2es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI-0571-2009es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI-0306-2011,es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/salud201200057018traes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/AP_061/10es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FOOD-CT-2006-036224-HIWATEes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2014SGR647es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2014SGR850es_ES
dc.rights.accessRightsopen accesses_ES


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