Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7792
Viral Proteins that Enhance Membrane Permeability
González M.E., Carrasco L. (2005) Viral Proteins that Enhance Membrane Permeability. In: Fischer W.B. (eds) Viral Membrane Proteins: Structure, Function, and Drug Design. Protein Reviews, vol 1. Springer, Boston, MA
This chapter is devoted to reviewing some characteristics of membrane permeabilization by viral proteins. In addition, the methodology used to assay enhanced permeability in animal cells is described. Finally, the design of selective viral inhibitors based on the modification of cellular membranes during virus entry or at late times of infection is also discussed.
Table of contents
1. Introduction 2. Measuring alterations in membrane permeability 2.1. The hygromycin B test 2.2. Entry of macromolecules into virus-infected cells 2.3. Other assays to test the entry or exit of macromolecules from virus-infected cells 3. Viral proteins that modify permeability 3.1. Viroporins 3.2. Viral glycoproteins that modify membrane permeability 4. Membrane permeabilization and drug design 4.1. Antibiotics and toxins that selectively enter virus-infected cells 4.2. Viroporin inhibitors 4.3. Antiviral agents that interfere with viral glycoproteins 5. Acknowledgments References Figures
Viroporins | Viral Glycoproteins | Membrane permeabilization | Antiviral agents | Viroporin inhibitors | Biological assays | HIV-1 | Poliovirus | HIV-1 gp41
Virus Release | Cell Membrane Permeability | Cytopathogenic Effect, Viral | Models, Biological | Membrane Proteins | Membrane Glycoproteins | Toxins, Biological
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- Protein Reviews Chapter 2005 ...