Show simple item record

dc.contributor.authorWhittemore, Kurt 
dc.contributor.authorDerevyanko, Aksinya
dc.contributor.authorMartinez Rodriguez, Paula 
dc.contributor.authorSerrano Ruiz, Rosa 
dc.contributor.authorPumarola, Martí
dc.contributor.authorBosch, Fàtima
dc.contributor.authorBlasco , MA 
dc.date.accessioned2019-06-13T08:45:05Z
dc.date.available2019-06-13T08:45:05Z
dc.date.issued2019-05-28
dc.identifier.citationAging (Albany NY).2019;11(10):2916-2948.es_ES
dc.identifier.issn1945-4589es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7774
dc.description.abstractNeurodegenerative diseases associated with old age such as Alzheimer's disease present major problems for society, and they currently have no cure. The telomere protective caps at the ends of chromosomes shorten with age, and when they become critically short, they can induce a persistent DNA damage response at chromosome ends, triggering secondary cellular responses such as cell death and cellular senescence. Mice and humans with very short telomeres owing to telomerase deficiencies have an earlier onset of pathologies associated with loss of the regenerative capacity of tissues. However, the effects of short telomeres in very low proliferative tissues such as the brain have not been thoroughly investigated. Here, we describe a mouse model of neurodegeneration owing to presence of short telomeres in the brain as the consequence of telomerase deficiency. Interestingly, we find similar signs of neurodegeneration in very old mice as the consequence of physiological mouse aging. Next, we demonstrate that delivery of telomerase gene therapy to the brain of these mice results in amelioration of some of these neurodegeneration phenotypes. These findings suggest that short telomeres contribute to neurodegeneration diseases with aging and that telomerase activation may have a therapeutic value in these diseases.es_ES
dc.description.sponsorshipWe would like to thank the CNIO (Centro Nacional de Investigaciones Oncológicas or “Spanish National Cancer Centre” in Madrid Spain) confocal microscope core, histopathology core, particularly Alba de Martino and Patricia González García, molecular imaging core, and animal facility for all of their help and assistance. We also thank Manuel Valiente for suggestions and advice. The viral vectors were produced by the lab of Fàtima Bosc. Fàtima Bosch is an ICREA Academia recipient,Generalitat de Catalunya, Spaines_ES
dc.language.isoenges_ES
dc.publisherImpact Journales_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/*
dc.subjectTERTes_ES
dc.subjectgene therapyes_ES
dc.subjectneurodegenerationes_ES
dc.subjecttelomerasees_ES
dc.titleTelomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in micees_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 3.0 Internacional*
dc.identifier.pubmedID31140977es_ES
dc.format.volume11es_ES
dc.format.number10es_ES
dc.format.page2916-2948es_ES
dc.identifier.doi10.18632/aging.101982es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderWorldwide Cancer Researches_ES
dc.contributor.funderFundación Marcelino Botínes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1945-4589es_ES
dc.relation.publisherversionhttps://doi.org/10.18632/aging.101982.es_ES
dc.identifier.journalAginges_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Telómeros y Telomerasaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-72455- EXPes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/S2017/BMD -3770es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


Files in this item

Acceso Abierto
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Atribución 3.0 Internacional
This item is licensed under a: Atribución 3.0 Internacional