Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7770
Título
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency
Autor(es)
Cogliati, Sara | Frezza, Christian | Soriano, Maria Eugenia | Varanita, Tatiana | Quintana-Cabrera, Ruben | Corrado, Mauro | Cipolat, Sara | Costa, Veronica | Casarin, Alberto | Gomes, Ligia C | Perales-Clemente, Ester CNIC | Salviati, Leonardo | Fernandez-Silva, Patricio | Enriquez, Jose Antonio CNIC | Scorrano, Luca
Fecha de publicación
2013-09
Cita
Cell. 2013; 155(1):160-71
Idioma
Inglés
Tipo de documento
journal article
Resumen
Respiratory chain complexes assemble into functional quaternary structures called supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or cristae. Here, we investigate the relationship between respiratory function and mitochondrial ultrastructure and provide evidence that cristae shape determines the assembly and stability of RCS and hence mitochondrial respiratory efficiency. Genetic and apoptotic manipulations of cristae structure affect assembly and activity of RCS in vitro and in vivo, independently of changes to mitochondrial protein synthesis or apoptotic outer mitochondrial membrane permeabilization. We demonstrate that, accordingly, the efficiency of mitochondria-dependent cell growth depends on cristae shape. Thus, RCS assembly emerges as a link between membrane morphology and function.
MESH
Amino Acid Sequence | Animals | Apoptosis | BH3 Interacting Domain Death Agonist Protein | GTP Phosphohydrolases | Humans | Mice | Mice, Inbred C57BL | Mitochondria | Mitochondrial Membranes | Molecular Sequence Data | Multiprotein Complexes | Sequence Alignment | Cell Respiration | Electron Transport
Versión en línea
DOI
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