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dc.contributor.authorLorente, Elena 
dc.contributor.authorGarcia, Ruth 
dc.contributor.authorMir-Gerrero, Carmen 
dc.contributor.authorBarriga, Alejandro 
dc.contributor.authorLemonnier, François A
dc.contributor.authorRamos, Manuel 
dc.contributor.authorLópez, Daniel 
dc.date.accessioned2019-06-04T06:48:31Z
dc.date.available2019-06-04T06:48:31Z
dc.date.issued2012-03-23
dc.identifier.citationJ Biol Chem. 2012;287(13):9990-10000.es_ES
dc.identifier.issn0021-9258es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7714
dc.description.abstractThe transporter associated with antigen processing (TAP) translocates the viral proteolytic peptides generated by the proteasome and other proteases in the cytosol to the endoplasmic reticulum lumen. There, they complex with nascent human leukocyte antigen (HLA) class I molecules, which are subsequently recognized by the CD8(+) lymphocyte cellular response. However, individuals with nonfunctional TAP complexes or tumor or infected cells with blocked TAP molecules are able to present HLA class I ligands generated by TAP-independent processing pathways. Herein, using a TAP-independent polyclonal vaccinia virus-polyspecific CD8(+) T cell line, two conserved vaccinia-derived TAP-independent HLA-B*0702 epitopes were identified. The presentation of these epitopes in normal cells occurs via complex antigen-processing pathways involving the proteasome and/or different subsets of metalloproteinases (amino-, carboxy-, and endoproteases), which were blocked in infected cells with specific chemical inhibitors. These data support the hypothesis that the abundant cellular proteolytic systems contribute to the supply of peptides recognized by the antiviral cellular immune response, thereby facilitating immunosurveillance. These data may explain why TAP-deficient individuals live normal life spans without any increased susceptibility to viral infections.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Society for Biochemistry and Molecular Biologyes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleRole of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentationes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID22298786es_ES
dc.format.volume287es_ES
dc.format.number13es_ES
dc.format.page9990-10000es_ES
dc.identifier.doi10.1074/jbc.M111.314856es_ES
dc.contributor.funderFundación para la Investigación y la Prevención del Sida en Españaes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1083-351Xes_ES
dc.relation.publisherversionhttps://www.doi.org/10.1074/jbc.M111.314856es_ES
dc.identifier.journalThe Journal of biological chemistryes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional