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dc.contributor.authorInfantes, Susana 
dc.contributor.authorLorente, Elena 
dc.contributor.authorBarnea, Eilon
dc.contributor.authorBeer, Ilan
dc.contributor.authorCragnolini, Juan José
dc.contributor.authorGarcia, Ruth 
dc.contributor.authorLasala, Fatima
dc.contributor.authorJimenez, Mercedes 
dc.contributor.authorAdmon, Arie
dc.contributor.authorLopez, Daniel 
dc.date.accessioned2019-06-03T07:19:20Z
dc.date.available2019-06-03T07:19:20Z
dc.date.issued2010-07
dc.identifier.citationMol Cell Proteomics. 2010;9(7):1533-9.es_ES
dc.identifier.issn1535-9476es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7705
dc.description.abstractCytotoxic T lymphocyte (CTL)-mediated death of virus-infected cells requires prior recognition of short viral peptide antigens that are presented by human leukocyte antigen (HLA) class I molecules on the surface of infected cells. The CTL response is critical for the clearance of human respiratory syncytial virus (HRSV) infection. Using mass spectrometry analysis of complex HLA-bound peptide pools isolated from large amounts of HRSV-infected cells, we identified nine naturally processed HLA-B27 ligands. The isolated peptides are derived from six internal, not envelope, proteins of the infective virus. The sequences of most of these ligands are not conserved between different HRSV strains, suggesting a mechanism to explain recurrent infection with virus of different HRSV antigenic subgroups. In addition, these nine ligands represent a significant fraction of the proteome of this virus, which is monitored by the same HLA class I allele. These data have implications for vaccine development as well as for analysis of the CTL response.es_ES
dc.description.sponsorshipThis work was supported by grants from the Programa Ramón y Cajal and the Fondo de Investigaciones Sanitarias de la Seguridad Social (to D. L.) and Israel Science Foundation Grant 916/05 (to A. A.).es_ES
dc.language.isoenges_ES
dc.publisherAmerican Society for Biochemistry and Molecular Biology (ASBMB) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleMultiple, non-conserved, internal viral ligands naturally presented by HLA-B27 in human respiratory syncytial virus-infected cellses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID20081153es_ES
dc.format.volume9es_ES
dc.format.number7es_ES
dc.format.page1533-9es_ES
dc.identifier.doi10.1074/mcp.M900508-MCP200es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderIsrael Science Foundation 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1535-9484es_ES
dc.relation.publisherversionhttps://www.doi.org/10.1074/mcp.M900508-MCP200es_ES
dc.identifier.journalMolecular & cellular proteomics : MCPes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/916/05es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional