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dc.contributor.authorJiménez-Navarro, Manuel F
dc.contributor.authorBueno, Héctor 
dc.contributor.authorÁlvarez-Sala, Luis
dc.contributor.authorRodríguez-Losada, Noela
dc.contributor.authorAndres, Vicente 
dc.contributor.authorGonzález-Navarro, Herminia
dc.date.accessioned2019-05-23T09:10:56Z
dc.date.available2019-05-23T09:10:56Z
dc.date.issued2011
dc.identifier.citationISRN Cardiol. 2011; 2011:740585es_ES
dc.identifier.issn2090-5580es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7660
dc.description.abstractThe mechanisms underlying the increased risk of cardiovascular disease associated with diabetes mellitus (DM) are not fully defined. Insulin resistance in human metabolic syndrome patients is associated with decreased expression of the insulin receptor substrate-2- (Irs2-) AKT2 axis in mononuclear leukocytes (MLs). Moreover, acute coronary syndrome (ACS) has been linked through genome-wide association studies to the 2q36-q37.3 locus, which contains the Irs1 gene. Here, we investigated the expression of insulin-signaling pathway genes in MLs from patients with DM, ACS, and ACS plus DM. Quantitative real-time PCR expression studies showed no differences in the mRNA levels of Irs2, Akt2, and Akt1 among all patients. However, Irs1 mRNA expression was significantly increased in patients with ACS-diabetics and nondiabetics-compared with diabetic patients without ACS (P < .02 and P < .005, resp.). The present study reveals for the first time an association between increased Irs1 mRNA levels in MLs of patients with ACS which is not related to DM.es_ES
dc.description.sponsorshipThis study was supported by grants from the Spanish Ministry of Science and Innovation (MICINN), the European Regional Development Fund (SAF2007-62110), and the Instituto de Salud Carlos III (Grant RD06/0014/0021, RECAVA). The CNIC is supported by Fundacion Pro-CNIC. H. Gonzalez Navarro was supported by the CSIC JAE-Doctor programme and the Miguel Servet programme (Instituto de Salud Carlos III CP10/00555).es_ES
dc.language.isoenges_ES
dc.publisherHindawies_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleInsulin receptor substrate-1 expression is increased in circulating leukocytes of patients with acute coronary syndromees_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID22347652es_ES
dc.format.volume2011es_ES
dc.format.page740585es_ES
dc.identifier.doi10.5402/2011/740585es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2090-5599es_ES
dc.relation.publisherversionhttps://doi.org/10.5402/2011/740585es_ES
dc.identifier.journalISRN cardiologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Fisiopatología Cardiovascular Molecular y Genéticaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2007-62110es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD06/0014/0021es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP10/00555es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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