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dc.contributor.authorLlamosas-Falcón, Laura
dc.contributor.authorBermejo-Sánchez, Eva 
dc.contributor.authorSanchez-Diaz, German 
dc.contributor.authorVillaverde-Hueso, Ana 
dc.contributor.authorPosada de la Paz, Manuel 
dc.contributor.authorAlonso-Ferreira, Veronica 
dc.date.accessioned2019-05-22T08:44:32Z
dc.date.available2019-05-22T08:44:32Z
dc.date.issued2019-04-08
dc.identifier.citationOrphanet J Rare Dis. 2019 Apr 8;14(1):79.es_ES
dc.identifier.issn1750-1172es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7647
dc.description.abstractBACKGROUND: Tetralogy of Fallot (TOF) is the most frequent cyanotic congenital heart defect. TOF mortality has fallen remarkably in recent years due to therapeutic advances. Accordingly, the aim of this study was to assess temporal and spatial variability in TOF-related mortality in Spain across the period 1981-2016, using data drawn from the nationwide population-based registry. METHODS: Annual deaths due to TOF were sourced from the Spanish National Institute of Statistics database by reference to International Classification of Diseases (ICD), 9th and 10th Revision codes, namely, ICD-9 code 745.2 (period 1981-1998) and ICD-10 code Q21.3 (period 1999-2016). Age-specific and age-adjusted mortality rates were calculated, as were standardised mortality ratios (SMRs) by province, district and municipality for the period 1999-2016. RESULTS: A total of 1035 deaths were attributed to TOF (57.78% of them were men and 42.22% were women). The age-adjusted mortality rate ranged from 0.75 per 1,000,000 inhabitants (95% confidence interval [CI]: 0-1.36) in 1981 to 0.03 per 1,000,000 (95% CI: 0.01-0.06) in 2016 for both sexes. In 2011, there was a change in the mortality trend, with a significant decrease of 49.22% per year (p < 0.001). In terms of geographical analysis, some areas with a significantly higher risk of TOF mortality were identified in the south of Spain, though no specific spatial pattern was in evidence. CONCLUSION: The decrease in TOF mortality may be related to improvements in diagnostic and treatment techniques. More studies are needed to analyse regions with a higher mortality risk, in order to improve medical planning and resource allocation, and identify risk factors and preventive measures.es_ES
dc.description.sponsorshipThis research was funded by Instituto de Salud Carlos III, Spanish Strategy Action for Health (AESI), project TPY1238/15. The author G.S.D. received a research grant from the Spanish Ministry of Education, Culture and Sport, FPU14/03914.es_ES
dc.language.isoenges_ES
dc.publisherBMCes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCongenital heart defectes_ES
dc.subjectMortalityes_ES
dc.subjectSpaines_ES
dc.subjectSpatial-analysises_ES
dc.subjectTemporal-analysises_ES
dc.subjectTetralogy of Fallotes_ES
dc.titleTetralogy of Fallot in Spain: a nationwide registry-based mortality study across 36 yearses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30961612es_ES
dc.format.volume14es_ES
dc.format.number1es_ES
dc.format.page79es_ES
dc.identifier.doi10.1186/s13023-019-1056-yes_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderMinisterio de Educación, Cultura y Deporte (España)
dc.description.peerreviewedes_ES
dc.identifier.e-issn1750-1172es_ES
dc.relation.publisherversionhttps://doi.org/10.1186/s13023-019-1056-yes_ES
dc.identifier.journalOrphanet journal of rare diseaseses_ES
dc.repisalud.centroISCIII::Instituto de Investigación de Enfermedades Rarases_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/TPY1238/15es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FPU14/03914es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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