Publication: Identification of a cluster of HIV-1 controllers infected with low replicating viruses
Loading...
Identifiers
Publication date
2013
Authors
Casado, Concepcion ISCIII 
Pernas, Maria ISCIII
Sandonis-Martin, Virginia ISCIII
Alvaro-Cifuentes, Tamara ISCIII
Olivares, Isabel ISCIII
Fuentes-Fernandez, Rosa ISCIII
Martínez-Prats, Lorena
Grau, Eulalia
Ruiz, Lidia
Delgado, Rafael
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science (PLOS)
Metrics
Export
Abstract
Long term non-progressor patients (LTNPs) are characterized by the natural control of HIV-1 infection. This control is related to host genetic, immunological and virological factors. In this work, phylogenetic analysis of the proviral nucleotide sequences in env gene from a Spanish HIV-1 LTNPs cohort identified a cluster of 6 HIV-1 controllers infected with closely-related viruses. The patients of the cluster showed common clinical and epidemiological features: drug user practices, infection in the same city (Madrid, Spain) and at the same time (late 70's-early 80's). All cluster patients displayed distinct host alleles associated with HIV control. Analysis of the virus envelope nucleotide sequences showed ancestral characteristic, lack of evolution and presence of rare amino-acids. Biological characterization of recombinant viruses with the envelope proteins from the cluster viruses showed very low replicative capacity in TZMbl and U87-CD4/CCR5 cells. The lack of clinical progression in the viral cluster patients with distinct combinations of protective host genotypes, but infected by low replicating viruses, indicate the important role of the virus in the non-progressor phenotype in these patients.
Description
Keywords
DeCS Terms
Bibliographic citation
PLoS One. 2013 Oct 30;8(10):e77663.