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dc.contributor.authorMagro-Lopez, Esmeralda 
dc.contributor.authorPalmer, Charlotte 
dc.contributor.authorManso, Joana 
dc.contributor.authorListe-Noya, Isabel 
dc.contributor.authorZambrano, Alberto 
dc.date.accessioned2019-05-17T10:41:20Z
dc.date.available2019-05-17T10:41:20Z
dc.date.issued2018
dc.identifier.citationStem Cell Res Ther. 2018 Jul 11;9(1):186es_ES
dc.identifier.issn1757-6512es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7587
dc.description.abstractOrganoids from human pluripotent stem cells are becoming suitable models for studies of organ development, drug screening, regenerative medicine, and disease modeling. Three-dimensional minilungs in Matrigel culture have recently been generated from human embryonic stem cells. These particular organoids, named lung bud organoids, showed branching airway and early alveolar structures resembling those present in lungs from the second trimester of human gestation. We show here that the treatment of such organoids with a lung and airway epithelial maturation cocktail containing dexamethasone drives lung bud organoids to the formation of paddle-racquet like structures. This strategy may help to increase the versatility of lung organoids and to generate structures more advanced than the original branching texture.es_ES
dc.description.sponsorshipThis work was supported by grants MPY-1038/14 and MPY-1146/16 from ISCIII to AZ and SAF-2015-71140-R from MINECO to IL.es_ES
dc.language.isoenges_ES
dc.publisherBMCes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDexamethasonees_ES
dc.subjectHuman embryonic stem cellses_ES
dc.subjectLung bud organoides_ES
dc.subjectLung epithelial maturation mediumes_ES
dc.subject.meshCell Culture Techniques es_ES
dc.subject.meshCell Differentiation es_ES
dc.subject.meshEmbryonic Stem Cells es_ES
dc.subject.meshEpithelial Cells es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLung es_ES
dc.subject.meshOrganoids es_ES
dc.titleEffects of lung and airway epithelial maturation cocktail on the structure of lung bud organoidses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29996941es_ES
dc.format.volume9es_ES
dc.format.number1es_ES
dc.format.page186es_ES
dc.identifier.doi10.1186/s13287-018-0943-9es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.description.peerreviewedes_ES
dc.identifier.e-issn1757-6512es_ES
dc.relation.publisherversionhttps://doi.org/10.1186/s13287-018-0943-9es_ES
dc.identifier.journalStem cell research & therapyes_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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