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dc.contributor.authorEvrard, Maximilien
dc.contributor.authorKwok, Immanuel W H
dc.contributor.authorChong, Shu Zhen
dc.contributor.authorTeng, Karen W W
dc.contributor.authorBecht, Etienne
dc.contributor.authorChen, Jinmiao
dc.contributor.authorSieow, Je Lin
dc.contributor.authorPenny, Hweixian Leong
dc.contributor.authorChing, Goh Chi
dc.contributor.authorDevi, Sapna
dc.contributor.authorAdrover, Jose M 
dc.contributor.authorLi, Jackson L Y
dc.contributor.authorLiong, Ka Hang
dc.contributor.authorTan, Leonard
dc.contributor.authorPoon, Zhiyong
dc.contributor.authorFoo, Shihui
dc.contributor.authorChua, Jia Wang
dc.contributor.authorSu, I-Hsin
dc.contributor.authorBalabanian, Karl
dc.contributor.authorBachelerie, Françoise
dc.contributor.authorBiswas, Subhra K
dc.contributor.authorLarbi, Anis
dc.contributor.authorHwang, William Y K
dc.contributor.authorMadan, Vikas
dc.contributor.authorKoeffler, H Phillip
dc.contributor.authorWong, Siew Cheng
dc.contributor.authorNewell, Evan W
dc.contributor.authorHidalgo, Andrés 
dc.contributor.authorGinhoux, Florent
dc.contributor.authorNg, Lai Guan
dc.date.accessioned2019-05-09T08:03:18Z
dc.date.available2019-05-09T08:03:18Z
dc.date.issued2018-02
dc.identifier.citationImmunity. 2018; 48(2):364-379es_ES
dc.identifier.issn10747613es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7557
dc.description.abstractNeutrophils are specialized innate cells that require constant replenishment from proliferative bone marrow (BM) precursors as a result of their short half-life. Although it is established that neutrophils are derived from the granulocyte-macrophage progenitor (GMP), the differentiation pathways from GMP to functional mature neutrophils are poorly defined. Using mass cytometry (CyTOF) and cell-cycle-based analysis, we identified three neutrophil subsets within the BM: a committed proliferative neutrophil precursor (preNeu) which differentiates into non-proliferating immature neutrophils and mature neutrophils. Transcriptomic profiling and functional analysis revealed that preNeu require the C/EBPε transcription factor for their generation from the GMP, and their proliferative program is substituted by a gain of migratory and effector function as they mature. preNeus expand under microbial and tumoral stress, and immature neutrophils are recruited to the periphery of tumor-bearing mice. In summary, our study identifies specialized BM granulocytic populations that ensure supply under homeostasis and stress responses.es_ES
dc.description.sponsorshipWe thank all members of L.G.N laboratory, the SIgN (Singapore Immunology Network) flow-cytometry team, the SIgN functional genomics team for their assistance with transcriptomics, and the SIgN mouse core facility for their technical help and support. This research was funded by SIgN core funding, A*STAR (Agency for Science, Technology and Research), Singapore.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGranulopoiesises_ES
dc.subjectneutrophil developmentes_ES
dc.subjectneutrophil ontogenyes_ES
dc.subjectneutrophil precursorses_ES
dc.subjecttraffickinges_ES
dc.subject.meshAnimals es_ES
dc.subject.meshBone Marrow Cells es_ES
dc.subject.meshCCAAT-Enhancer-Binding Proteins es_ES
dc.subject.meshCell Lineage es_ES
dc.subject.meshCell Movement es_ES
dc.subject.meshCell Proliferation es_ES
dc.subject.meshCells, Cultured es_ES
dc.subject.meshGene Expression Profiling es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMice es_ES
dc.subject.meshNeoplasms, Experimental es_ES
dc.subject.meshNeutrophils es_ES
dc.titleDevelopmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functionses_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID29466759es_ES
dc.format.volume48es_ES
dc.format.number2es_ES
dc.format.page364-379.e8es_ES
dc.identifier.doi10.1016/j.immuni.2018.02.002es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1097-4180es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.immuni.2018.02.002es_ES
dc.identifier.journalImmunityes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional