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dc.contributor.authorBaixauli, Francesc 
dc.contributor.authorLópez-Otín, Carlos
dc.contributor.authorMittelbrunn, Maria 
dc.date.accessioned2019-04-29T12:43:57Z
dc.date.available2019-04-29T12:43:57Z
dc.date.issued2014
dc.identifier.citationFront Immunol. 2014; 5:403es_ES
dc.identifier.issn1664-3224es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7534
dc.description.abstractConditions resulting from loss of cellular homeostasis, including oxidative stress, inflammation, protein aggregation, endoplasmic reticulum stress, metabolic stress, and perturbation of mitochondrial function, are common to many pathological disorders and contribute to aging. Cells face these stress situations by engaging quality control mechanisms aimed to restore cellular homeostasis and preserve cell viability. Among them, the autophagy-lysosomal pathway mediates the specific degradation of damaged proteins and organelles, and its proper function is related to cellular protection and increased life span in many model organisms. Besides autophagy, increasing evidence underscores a role for exosomes in the selective secretion of harmful/damaged proteins and RNAs and thus in the maintenance of cellular fitness. In this perspective article, we discuss the emerging function of exosomes as a means of alleviating intracellular stress conditions, and how secretion of harmful or unwanted material in exosomes, in coordination with the autophagy-lysosomal pathway, is essential to preserve intracellular protein and RNA homeostasis. Finally, we provide an overview about the consequences of the spreading of the exosome content in physiological and pathological situations, and suggest putative therapeutic strategies for these exosome-mediated alterations.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAginges_ES
dc.subjectAutophagyes_ES
dc.subjectEndosomees_ES
dc.subjectExosomeses_ES
dc.subjectLysosomees_ES
dc.subjectMultivesicular bodieses_ES
dc.subjectNeurodegenerationes_ES
dc.subjectProteostasises_ES
dc.subjectSpreadinges_ES
dc.titleExosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitnesses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID25191326es_ES
dc.format.volume5es_ES
dc.format.page403es_ES
dc.identifier.doi10.3389/fimmu.2014.00403es_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2014.00403es_ES
dc.identifier.journalFrontiers in immunologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoriaes_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional