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dc.contributor.authorLópez-Guimerà, Gemma
dc.contributor.authorDashti, Hassan S
dc.contributor.authorSmith, Caren E
dc.contributor.authorSánchez-Carracedo, David
dc.contributor.authorOrdovas, Jose M 
dc.contributor.authorGaraulet, Marta
dc.identifier.citationPLoS One. 2014; 9(6):e99152es_ES
dc.description.abstractOBJECTIVE: The goals of this research was (1) to analyze the role of emotional eating behavior on weight-loss progression during a 30-week weight-loss program in 1,272 individuals from a large Mediterranean population and (2) to test for interaction between CLOCK 3111 T/C SNP and emotional eating behavior on the effectiveness of the weight-loss program. DESIGN AND METHODS: A total of 1,272 overweight and obese participants (BMI: 31±5 kg/m2), aged 20 to 65 years, attending outpatient weight-loss clinics were recruited for this analysis. Emotional eating behavior was assessed by the Emotional Eating Questionnaire (EEQ), a questionnaire validated for overweight and obese Spanish subjects. Anthropometric measures, dietary intake and weight-loss progression were assessed and analyzed throughout the 30-week program. Multivariate analysis and linear regression models were performed to test for gene-environment interaction. RESULTS: Weight-loss progression during the 30-week program differed significantly according to the degree of emotional eating behavior. Participants classified as 'very emotional eaters' experienced more irregular (P = 0.007) weight-loss, with a lower rate of weight decline (-0.002 vs. -0.003, P<0.05) in comparison with less emotional eaters. The percentage of weight-loss was also significantly higher in 'non-emotional eaters' (P = 0.009). Additionally, we identified a significant gene-environment interaction associated with weight-loss at the CLOCK 3111 T/C locus (P = 0.017). By dichotomizing the emotional eating behavior score, linear regression analysis indicated that minor C allele carriers with a high emotional score (> = 11), lost significantly less weight than those C carriers with a low emotional score (<11) (P = 0.005). CONCLUSIONS: Emotional eating behavior associates with weight-loss pattern, progression and total weight-loss. Additionally, CLOCK 3111 T/C SNP interacts with emotional eating behavior to modulate total weight loss. These results suggest that the assessment of this locus and emotional eating behavior could improve the development of effective, long-tern weight-management interventions.es_ES
dc.description.sponsorshipThis study was supported by grants from the Tomas Pascual and Pilar Gomez-Cuetara Foundations, the Spanish Government of Science and Innovation (BFU2011-24720), and Seneca Foundation from the Government of Murcia (15123/PI/10). National Heart, Lung, and Blood Institute grants HL-54776, National Institute of Diabetes and Digestive and Kidney Diseases, Grant Number DK075030 and by contracts 53-K06-5-10 and 58-1950-9-001 from the US Departmentof Agriculture Research.es_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshAdult es_ES
dc.subject.meshAged es_ES
dc.subject.meshCLOCK Proteins es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMediterranean Region es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshAffective Symptoms es_ES
dc.subject.meshDiet, Mediterranean es_ES
dc.subject.meshFeeding Behavior es_ES
dc.subject.meshObesity es_ES
dc.subject.meshPolymorphism, Single Nucleotidees_ES
dc.subject.meshWeight Loss es_ES
dc.titleCLOCK 3111 T/C SNP interacts with emotional eating behavior for weight-loss in a Mediterranean populationes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderFundación Tomás Pascual y Pilar Gómez-Cuétara
dc.contributor.funderMinisterio de Ciencia e Innovación (España)
dc.contributor.funderFundación Séneca
dc.contributor.funderRegión de Murcia
dc.contributor.funderNational Heart, Lung, and Blood Institute (United States)
dc.contributor.funderNational Institute of Diabetes and Digestive and Kidney Diseases (United States)
dc.contributor.funderDepartment of Agriculture (United States)
dc.identifier.journalPloS onees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES

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Atribución 4.0 Internacional
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