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dc.contributor.authorSanz-Navarro, Maria
dc.contributor.authorDelgado, Irene 
dc.contributor.authorTorres, Miguel 
dc.contributor.authorMustonen, Tuija
dc.contributor.authorMichon, Frederic
dc.contributor.authorRice, David P
dc.date.accessioned2019-04-25T09:44:33Z
dc.date.available2019-04-25T09:44:33Z
dc.date.issued2019
dc.identifier.citationFront Physiol. 2019; 10:249es_ES
dc.identifier.issn1664-042Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7506
dc.description.abstractMEIS1 is a key developmental regulator of several organs and participates in stem cell maintenance in different niches. However, despite the murine continuously growing incisor being a well described model for the study of adult stem cells, Meis1 has not been investigated in a dental context. Here, we uncover that Meis1 expression in the tooth is confined to the epithelial compartment. Its expression arises during morphogenesis and becomes restricted to the mouse incisor epithelial stem cell niche, the labial cervical loop. Meis1 is specifically expressed by Sox2+ stem cells, which give rise to all dental epithelial cell lineages. Also, we have found that Meis1 in the incisor is coexpressed with potential binding partner Pbx1 during both embryonic and adult stages. Interestingly, Meis2 is present in different areas of the forming tooth and it is not expressed by dental epithelial stem cells, suggesting different roles for these two largely homologous genes. Additionally, we have established the expression patterns of Meis1 and Meis2 during tongue, hair, salivary gland and palate formation. Finally, analysis of Meis1-null allele mice indicated that, similarly, to SOX2, MEIS1 is not essential for tooth initiation, but might have a role during adult incisor renewal.es_ES
dc.description.sponsorshipThis study was funded by Minerva Foundation (Selma and Maja-Lisa Selander's fund) and FINDOS to MS-N, the Academy of Finland to FM and University of Helsinki Research Foundation (Y1014SL009) to DR.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMEIS1es_ES
dc.subjectSOX2es_ES
dc.subjectectodermal organes_ES
dc.subjectMouse incisores_ES
dc.subjectPalatees_ES
dc.subjectStem cellses_ES
dc.subjectTonguees_ES
dc.subjectTooth developmentes_ES
dc.titleDental Epithelial Stem Cells Express the Developmental Regulator Meis1es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30914971es_ES
dc.format.volume10es_ES
dc.format.page249es_ES
dc.identifier.doi10.3389/fphys.2019.00249es_ES
dc.contributor.funderMinerva Foundation 
dc.contributor.funderUniversity of Helsinki (Finlandia) 
dc.contributor.funderFinlands Akademi (Finlandia) 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fphys.2019.00249es_ES
dc.identifier.journalFrontiers in physiologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Control Genético del Desarrollo y Regeneración de Órganoses_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional