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dc.contributor.authorCuadrado-Corrales, Natividad 
dc.contributor.authorJiménez-Huete, Adolfo
dc.contributor.authorAlbo, Carmen 
dc.contributor.authorHortigüela, Rafael 
dc.contributor.authorVega, Luz 
dc.contributor.authorCerrato, Laura 
dc.contributor.authorSierra Moros, María José
dc.contributor.authorRábano, Alberto
dc.contributor.authorPedro-Cuesta, Jesus de 
dc.contributor.authorCalero, Miguel
dc.identifier.citationBMC Neurol. 2006 Jul 26;6:25.es_ES
dc.description.abstractBACKGROUND: The 14-3-3 test appears to be a valuable aid for the clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) in selected populations. However, its usefulness in routine practice has been challenged. In this study, the influence of the clinical context on the performance of the 14-3-3 test for the diagnosis of sCJD is investigated through the analysis of a large prospective clinical series. METHODS: Six hundred seventy-two Spanish patients with clinically suspected sCJD were analyzed. Clinical classification at sample reception according to the World Health Organization's (WHO) criteria (excluding the 14-3-3 test result) was used to explore the influence of the clinical context on the pre-test probabilities, and positive (PPV) and negative (NPV) predictive values of the 14-3-3 test. RESULTS: Predictive values of the test varied greatly according to the initial clinical classification: PPV of 98.8%, 96.5% and 45.0%, and NPV of 26.1%, 66.6% and 100% for probable sCJDi (n = 115), possible sCJDi (n = 73) and non-sCJDi (n = 484) cases, respectively. According to multivariate and Bayesian analyses, these values represent an improvement of diagnostic certainty compared to clinical data alone. CONCLUSION: In three different contexts of sCJD suspicion, the 14-3-3 assay provides useful information complementary to clinical and electroencephalographic (EEG) data. The test is most useful supporting a clinical impression, whilst it may show deceptive when it is not in agreement with clinical data.es_ES
dc.description.sponsorshipThis work was supported through unrestricted grants by the DGSP of the Spanish National Health Ministry and CIEN (C03/06) research network to JPC and MC, and RCESP (C03–09) research network to JPC.es_ES
dc.publisherBioMed Centrales_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.mesh14-3-3 Proteins es_ES
dc.subject.meshAdult es_ES
dc.subject.meshAged es_ES
dc.subject.meshAged, 80 and over es_ES
dc.subject.meshCreutzfeldt-Jakob Syndrome es_ES
dc.subject.meshFemale es_ES
dc.subject.meshFollow-Up Studies es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPredictive Value of Tests es_ES
dc.subject.meshProspective Studies es_ES
dc.subject.meshClinical Laboratory Techniques es_ES
dc.titleImpact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJDes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderMinisterio de Sanidad y Consumo (España)es_ES
dc.identifier.journalBMC neurologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES

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