Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7378
Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD
Cuadrado-Corrales, Natividad ISCIII | Jiménez-Huete, Adolfo | Albo, Carmen ISCIII | Hortigüela, Rafael ISCIII | Vega, Luz ISCIII | Cerrato, Laura ISCIII | Sierra Moros, María José | Rábano, Alberto | Pedro-Cuesta, Jesus de ISCIII | Calero, Miguel ISCIII
BMC Neurol. 2006 Jul 26;6:25.
BACKGROUND: The 14-3-3 test appears to be a valuable aid for the clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) in selected populations. However, its usefulness in routine practice has been challenged. In this study, the influence of the clinical context on the performance of the 14-3-3 test for the diagnosis of sCJD is investigated through the analysis of a large prospective clinical series. METHODS: Six hundred seventy-two Spanish patients with clinically suspected sCJD were analyzed. Clinical classification at sample reception according to the World Health Organization's (WHO) criteria (excluding the 14-3-3 test result) was used to explore the influence of the clinical context on the pre-test probabilities, and positive (PPV) and negative (NPV) predictive values of the 14-3-3 test. RESULTS: Predictive values of the test varied greatly according to the initial clinical classification: PPV of 98.8%, 96.5% and 45.0%, and NPV of 26.1%, 66.6% and 100% for probable sCJDi (n = 115), possible sCJDi (n = 73) and non-sCJDi (n = 484) cases, respectively. According to multivariate and Bayesian analyses, these values represent an improvement of diagnostic certainty compared to clinical data alone. CONCLUSION: In three different contexts of sCJD suspicion, the 14-3-3 assay provides useful information complementary to clinical and electroencephalographic (EEG) data. The test is most useful supporting a clinical impression, whilst it may show deceptive when it is not in agreement with clinical data.
14-3-3 Proteins | Adult | Aged | Aged, 80 and over | Creutzfeldt-Jakob Syndrome | Female | Follow-Up Studies | Humans | Male | Middle Aged | Predictive Value of Tests | Prospective Studies | Clinical Laboratory Techniques
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