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dc.contributor.authorÁlvaro-Meca, Alejandro
dc.contributor.authorJimenez-Sousa, Maria Angeles 
dc.contributor.authorMicheloud, Dariela
dc.contributor.authorSánchez-Lopez, Ainhoa
dc.contributor.authorHeredia-Rodríguez, María
dc.contributor.authorTamayo, Eduardo
dc.contributor.authorResino, Salvador 
dc.contributor.authorGroup of Biomedical Research in Critical Care Medicine (BioCritic)
dc.contributor.authorFernandez-Rodriguez, Amanda 
dc.contributor.authorMartinez, Isidoro
dc.identifier.citationPopul Health Metr. 2018 Feb 12;16(1):4es_ES
dc.description.abstractBACKGROUND: Sepsis has represented a substantial health care and economic burden worldwide during the previous several decades. Our aim was to analyze the epidemiological trends of hospital admissions, deaths, hospital resource expenditures, and associated costs related to sepsis during the twenty-first century in Spain. METHODS: We performed a retrospective study of all sepsis-related hospitalizations in Spanish public hospitals from 2000 to 2013. Data were obtained from records in the Minimum Basic Data Set. The outcome variables were sepsis, death, length of hospital stay (LOHS), and sepsis-associated costs. The study period was divided into three calendar periods (2000-2004, 2005-2009, and 2010-2013). RESULTS: Overall, 2,646,445 patients with sepsis were included, 485,685 of whom had died (18.4%). The incidence of sepsis (events per 1000 population) increased from 3.30 (2000-2004) to 4.28 (2005-2009) to 4.45 (2010-2013) (p < 0.001). The mortality rates from sepsis (deaths per 10,000 population) increased from 6.34 (2000-2004) to 7.88 (2005-2009) to 7.89 (2010-2013) (p < 0.001). The case fatality rate (CFR) or proportion of patients with sepsis who died decreased from 19.1% (2000-2004) to 18.4% (2005-2009) to 17.9% (2010-2013) (p < 0.001). The LOHS (days) decreased from 15.9 (2000-2004) to 15.7 (2005-2009) to 14.5 (2010-2013) (p < 0.001). Total and per patient hospital costs increased from 2000 to 2011, and then decreased by the impact of the economic crisis. CONCLUSIONS: Sepsis has caused an increasing burden in terms of hospital admission, deaths, and costs in the Spanish public health system during the twenty-first century, but the incidence and mortality seemed to stabilize in 2010-2013. Moreover, there was a significant decrease in LOHS in 2010-2013 and a decline in hospital costs after 2011.es_ES
dc.description.sponsorshipThis research has been supported by Instituto de Salud Carlos III (grant numbers PI14CIII/00011 to SR, PI12/00019 to AAM, and PI15/01451 to ET), and “Gerencia de Salud, Consejería de Sanidad, Junta de Castilla y Leon” [grant number 773/A/13 to ET]. MAJS is supported by a contract of “Instituto de Salud Carlos III” (grant number CD13/00013).es_ES
dc.publisherBioMed Central (BMC) es_ES
dc.subjectCase fatality ratees_ES
dc.subjectHospital resourceses_ES
dc.subjectLength of hospital stayes_ES
dc.subject.meshAged es_ES
dc.subject.meshAged, 80 and over es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHospital Costs es_ES
dc.subject.meshHospital Mortality es_ES
dc.subject.meshHospitalization es_ES
dc.subject.meshHospitals, Public es_ES
dc.subject.meshHumans es_ES
dc.subject.meshIncidence es_ES
dc.subject.meshLength of Stay es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshRetrospective Studies es_ES
dc.subject.meshSepsis es_ES
dc.subject.meshSpain es_ES
dc.titleEpidemiological trends of sepsis in the twenty-first century (2000-2013): an analysis of incidence, mortality, and associated costs in Spaines_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderJunta de Castilla y León (España) 
dc.identifier.journalPopulation health metricses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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