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dc.contributor.authorMoreno-Gonzalo, Olga 
dc.contributor.authorVillarroya-Beltri, Carolina 
dc.contributor.authorSanchez-Madrid, Francisco 
dc.date.accessioned2019-03-18T14:41:32Z
dc.date.available2019-03-18T14:41:32Z
dc.date.issued2014
dc.identifier.citationFront Immunol. 2014; 5:383es_ES
dc.identifier.issn1664-3224es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7355
dc.description.abstractExosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection. Exosomes are small vesicles secreted to the extracellular environment through the release of intraluminal vesicles contained in multivesicular bodies (MVBs) upon the fusion of these MVBs with the plasma membrane. The composition of exosomes is not random, suggesting that the incorporation of cargo into them is a regulated process. However, the mechanisms that control the sorting of protein cargo into exosomes are currently elusive. Here, we review the post-translational modifications detected in exosomal proteins, and discuss their possible role in their specific sorting into exosomes.es_ES
dc.description.sponsorshipThis work was supported by SAF2011-25834 fromthe Spanish Ministry of Science and Innovation. INDISNET-S2011/BMD2332 from the Comunidad de Madrid, Red Cardiovascular RD 12-0042-0056 from Instituto Salud Carlos III (ISCIII), ERC2011-AdG 294340-GENTRIS, and COST-Action BN1202. Olga Moreno-Gonzalo and Carolina Villarroya-Beltri were supported by FPU program (Spanish Ministry of Education).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers in Biosciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectexosomeses_ES
dc.subjectmultivesicular bodieses_ES
dc.subjectpost-translational modificationses_ES
dc.subjectsortinges_ES
dc.subjectubiquitinationes_ES
dc.titlePost-translational modifications of exosomal proteinses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID25157254es_ES
dc.format.volume5es_ES
dc.format.page383es_ES
dc.identifier.doi10.3389/fimmu.2014.00383es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)
dc.contributor.funderComunidad de Madrid
dc.contributor.funderRed de Investigación Cardiovascular (España)
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderEuropean Commission
dc.contributor.funderEuropean Research Council
dc.contributor.funderMinisterio de Educación y Ciencia (España)
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2014.00383es_ES
dc.identifier.journalFrontiers in immunologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoriaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/294340/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2011-25834es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12-0042-0056es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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