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dc.contributor.authorPernaute, Barbara
dc.contributor.authorSpruce, Thomas
dc.contributor.authorSmith, Kimberley M
dc.contributor.authorSánchez-Nieto, Juan Miguel
dc.contributor.authorManzanares, Miguel 
dc.contributor.authorCobb, Bradley
dc.contributor.authorRodríguez, Tristan A
dc.date.accessioned2019-03-18T14:01:40Z
dc.date.available2019-03-18T14:01:40Z
dc.date.issued2014-09-01
dc.identifier.citationGenes Dev. 2014; 28(17):1873-8es_ES
dc.identifier.issn0890-9369es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7353
dc.description.abstractMammalian primed pluripotent stem cells have been shown to be highly susceptible to cell death stimuli due to their low apoptotic threshold, but how this threshold is regulated remains largely unknown. Here we identify microRNA (miRNA)-mediated regulation as a key mechanism controlling apoptosis in the post-implantation epiblast. Moreover, we found that three miRNA families, miR-20, miR-92, and miR-302, control the mitochondrial apoptotic machinery by fine-tuning the levels of expression of the proapoptotic protein BIM. These families therefore represent an essential buffer needed to maintain cell survival in stem cells that are primed for not only differentiation but also cell death.es_ES
dc.description.sponsorshipM.M. was supported by the Spanish Government and the ProCNIC Foundation. This work was supported by the Medical Research Council (MR/K00090X/1), EMBO (ALTF 1340-2010), and the European Commission (PIEF-GA-2010-273884 - MEMD).es_ES
dc.language.isoenges_ES
dc.publisherCold Spring Harbor Laboratory Presses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBimes_ES
dc.subjectDiceres_ES
dc.subjectapoptosises_ES
dc.subjectepiblastes_ES
dc.subjectmicroRNAses_ES
dc.subjectpluripotencyes_ES
dc.subject.meshAnimals es_ES
dc.subject.meshApoptosis es_ES
dc.subject.meshApoptosis Regulatory Proteins es_ES
dc.subject.meshBcl-2-Like Protein 11 es_ES
dc.subject.meshCell Survival es_ES
dc.subject.meshCells, Cultured es_ES
dc.subject.meshGene Expression Profiling es_ES
dc.subject.meshMembrane Proteins es_ES
dc.subject.meshMice es_ES
dc.subject.meshMicroRNAs es_ES
dc.subject.meshMitochondria es_ES
dc.subject.meshPluripotent Stem Cells es_ES
dc.subject.meshProto-Oncogene Proteins es_ES
dc.subject.meshGene Expression Regulation, Developmental es_ES
dc.titleMicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIMes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID25184675es_ES
dc.format.volume28es_ES
dc.format.number17es_ES
dc.format.page1873-8es_ES
dc.identifier.doi10.1101/gad.245621.114es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderMedical Research Council (United Kingdom)es_ES
dc.contributor.funderEuropean Molecular Biology Organization (EMBO)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1549-5477es_ES
dc.relation.publisherversionhttps://doi.org/10.1101/gad.245621.114es_ES
dc.identifier.journalGenes & developmentes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Genómica Funcionales_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/273884/EUes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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