Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7353
MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM
Genes Dev. 2014; 28(17):1873-8
Mammalian primed pluripotent stem cells have been shown to be highly susceptible to cell death stimuli due to their low apoptotic threshold, but how this threshold is regulated remains largely unknown. Here we identify microRNA (miRNA)-mediated regulation as a key mechanism controlling apoptosis in the post-implantation epiblast. Moreover, we found that three miRNA families, miR-20, miR-92, and miR-302, control the mitochondrial apoptotic machinery by fine-tuning the levels of expression of the proapoptotic protein BIM. These families therefore represent an essential buffer needed to maintain cell survival in stem cells that are primed for not only differentiation but also cell death.
Animals | Apoptosis | Apoptosis Regulatory Proteins | Bcl-2-Like Protein 11 | Cell Survival | Cells, Cultured | Gene Expression Profiling | Membrane Proteins | Mice | MicroRNAs | Mitochondria | Pluripotent Stem Cells | Proto-Oncogene Proteins | Gene Expression Regulation, Developmental
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